慢性乙型肝炎与肝硬化患者SEN病毒感染危险因素分析

Risk factors for SEN virus infection in patients with chronic hepatitis B and liver cirrhosis

目的分析和探讨慢性乙型肝炎与肝硬化患者感染SEN病毒的危险因素及采取的护理措施。方法选取医院2011年3月-2013年6月收治的慢性乙型肝炎与肝硬化患者为研究对象,使用SEN-V PCR引物探讨SEN病毒和慢性肝炎的关系,比较在病毒感染因素的作用下患者感染SEN病毒的概率;采用SPSS12.0软件进行统计分析。结果 SEN病毒主要有输血传播、静脉吸毒、母婴垂直传播以及性传播等传播途径,临床上常表现为SEN病毒单独感染和HBV等病毒合并感染;接受输血、有吸毒史、经母婴传播和性病慢性乙型肝炎与肝硬化患者的感染率分别为31.58%、36.84%、40.00%、34.38%,而未接受输血、无吸毒史、未经母婴传播和非性病患者的感染率为3.53%、3.73%、4.24%、5.41%,各组间比较差异均有统计学意义(P<0.01)。结论输血治疗和接触血制品、静脉吸毒、母婴以及性交等途径是慢性乙型肝炎与肝硬化患者感染SEN病毒的主要危险因素,患者应加强预防和防范,采取必要的安全护理措施,降低感染SEN病毒的概率。

OBJECTIVE To explore the risk factors for SEN virus infection in patients with chronic hepatitis B and liver cirrhosis and put forward nursing countermeasures.METHODS The patients with chronic hepatitis B and liver cirrhosis,who were treated in the hospital from Mar 2011to Jun 2013,were enrolled in the study,then the relationship between the SEN virus and the chronic hepatitis was studied with the use of SEN-V PCR primers,the incidence of SEN virus infection was observed under the influence of the risk factors,and the statistical analysis was performed by means of the SPSS12.0software.RESULTS The SEN virus transmitted mainly through the blood transfusion,intravenous use of drugs,vertical transmission from mother to infant,and sexual behaviors.The single SEN virus infection and the mixed SEN and HBV infections were the common clinical manifestations.The infection rate was 31.58%in the patients with chronic hepatitis B and liver cirrhosis receiving blood transfusion, 36.84%in the patients with the history of drug abuse,40.00% in the patients with mother-to-infant vertical transmission,34.38%in the patients with sexually transmitted diseases.The infection rate was 3.53%in the patients without receiving blood transfusion,3.73%in the patients without history of drug abuse,4.24%in the patients without mother-to-infant vertical transmission,5.41%in the patients without sexually transmitted diseases, the differences were significant（P＆lt;0.01）.CONCLUSIONThe blood transfusion,contact to blood products,intravenous use of drugs,mother-to-infant transmissions,and sexual behaviors are the major risk factors for the SEN virus infection in the patients with chronic hepatitis B and liver cirrhosis.It is necessary for the patients to strengthen the prevention and protection and take nursing countermeasures so as to reduce the incidence of SEN virus infection.