环境内分泌干扰化合物干扰胰岛素分泌潜在作用机理

Potential Mechanisms of Effects of Environmental Endocrine Disrupting Chemicals on Disrupting Insulin Secretion

不断升高的糖尿病发病率在全球范围内引起广泛关注,流行病学调查显示糖尿病发病率的增加与环境内分泌干扰化合物使用量增大之间存在显著相关,环境内分泌干扰化合物可能增加糖尿病发病风险,是影响糖尿病的危险因素。在此背景下,综述了环境内分泌干扰化合物暴露与糖尿病发病之间的流行病学关系;环境内分泌干扰化合物暴露对胰岛β细胞胰岛素分泌的调节、高胰岛素效应及其潜在的作用机理,表明影响胰岛素分泌是环境内分泌干扰化合物调节代谢,诱发糖尿病的重要作用机制。

The increasing incidence of diabetes has attracted worldwide attention. The epidemiological surveyshows significant correlation between increased incidence of diabetes and the rising use of environmental en-docrine disrupting chemicals （EDCs）. EDCs may increase the risk of diabetes, thus a dangerous factor causingdiabetes. Under such background, this article reviewed the epidemiological relation between exposure of EDCsand outbreak of diabetes, the insulin-secretion regulation of EDCs in pancreatic 13 cells, its insulinotropiceffects and potential action mechanisms. All of these suggest the importance of EDCs in inducing diabetesthrough its action mechanism of insulin-secretion regulation.