血小板增多与胃癌关系的初步研究

Preliminary study on the relationship between thrombocytosis and gastric cancer

目的 探讨血小板增多与胃癌临床病理分期和预后的关系.方法 回顾性分析2005年1月至2007年1月安徽医科大学第一附属医院经组织病理学确诊的156例胃癌患者的临床资料,电话随访患者的生存情况.统计不同临床分期患者血小板增多的发生率,比较血小板增多组和血小板不增多组患者的生存情况.结果 156例胃癌患者初诊时血小板增多32例（20.5％）,Ⅰ、Ⅱ、Ⅲ、Ⅳ期患者血小板增多发生率依次为4.8％、21.7％、24.4％、30.4％,各分期间差异有统计学意义（χ^2=8.768,P=0.003）.血小板增多组的1年、3年生存率分别为59.4％和34.4％,明显低于血小板未增多组的81.5％（χ^2=6.984,P=0.008）和63.7％（χ^2 =8.968,P=0.003）.结论 胃癌患者临床病理分期越晚,血小板增多的比率越大.血小板增多患者预后较差.

Objective To explore the relationship between thrombocytosis and gastric cancer at the points of clinicopathological stage and prognosis.Methods The clinical data of 156 gastric cancer patients from January 2005 to January 2007 were retrospectively analyzed,and the status of patients was obtained through telephone calls.The frequency of patients with thrombocytosis in different clinicopathological stages was analyzed,and comparison of survival time was made between normal PLT groups and thrombocytosis groups.Results 20.5% patients with gastric cancer were accompanied with thrombocytosis in 156 cases,and the frequency of patients with thrombocytosis in Ⅰ,Ⅱ,Ⅲ,Ⅳ stage were 4.8%,21.7%,24.4%,30.4%,and the difference was statistically significante （χ^2 =8.768,P =0.003）.Patients with thrombocytosis had a shorter survival time than those with normal platelet counts （one year survival rate：59.4% vs 81.5%,χ^2 =6.984,P =0.008 ; three years survival rate：34.4% vs 63.7%,χ^2 =8.968,P =0.003）.Conclusion In gastric cancer,thrombocytosis is associated with TNM stage.The gastric cancer patients with thrombocytosis have poorer prognosis than those without thrombocytosis.