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游离脂肪酸与骨骼肌胰岛素抵抗的研究进展 被引量：3

Research progress of free fatty acid and insulin resistance in skeletal muscle
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摘要 胰岛素抵抗与肥胖、2型糖尿病、高血压、脂代谢紊乱、异常血凝及纤溶等代谢综合征的发生和发展密切相关。虽然胰岛素抵抗发生机制尚不完全清楚,但大量研究表明游离脂肪酸在机体胰岛素抵抗,特别是骨骼肌胰岛素抵抗方面发挥重要作用。本文就游离脂肪酸引起骨骼肌胰岛素抵抗的作用及其机制进行综述,以期为胰岛素抵抗的改善及治疗带来新的手段。 Insulin resistance is strongly associated with metabolic syndrome characterized by obesity,type 2 diabetes, hypertension,dyslipidemia,abnormalities of blood coagulation and fibrinolysis.The precise mechanisms linking insulin resistance to these syndromes have not been completely defined.A growing body of evidence suggests that the elevated plasma free fatty acid level plays an important role in the development of insulin resistance,especially skeletal muscle insulin resistance.In the present review,to discuss the mechanism involved in the regulation of insulin sensitivity by free fatty acids in order to improve the insulin resistance and bring new means.
作者 瞿文娟 李志勇
机构地区 重庆医科大学附属永川医院内分泌科
出处 《中国当代医药》 2014年第13期186-188,共3页 China Modern Medicine
关键词 游离脂肪酸 骨骼肌 胰岛素抵抗 代谢综合征 Free fatty acid Skeletal muscle Insulin resistance Metabolic syndrome
分类号 R589 [医药卫生—内分泌]
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参考文献24

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同被引文献53

  • 1马静,金季玲.补肾化痰法治疗肥胖型多囊卵巢综合征30例[J].山东中医杂志,2007,26(8):537-538. 被引量：18
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  • 7Silfen M E, Denburg M R, Manibo A M. Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents. J Clin Endocrinol Metab, 2003, 88(10):4682-4688.
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  • 9Pasquali R, Gambineri A. Insulin sensitizers for polyeystie ovary syndrome. Clin Obstet Gynecol, 2003, 46(2):325-340.
  • 10Nelson-Degave V L, Wickenheisser J K, Hendricks K L, et aL Alterations in mitogen-activated protein kinase and extracellular regulated kinase signaling in theca cells contribute to excessive androgen production in polycystic ovary syndrome. Mol Endoevinol, 2005, 19(2):379-390.

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中国当代医药
2014年 第13期

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