依巴斯汀治疗慢性自发性荨麻疹的疗效和安全性被引量：1

Efficacy and Safety of Ebastine in the Treatment of Chronic Spontaneous Urticaria

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摘要目的观察双倍剂量的依巴斯汀和常规剂量依巴斯汀联合富马酸酮替芬片治疗慢性自发性荨麻疹的疗效和安全性。方法将受试者随机分为两组,治疗组予双倍剂量的依巴斯汀,对照组予常规剂量的依巴斯汀联合富马酸酮替芬片,观察两组的疗效和安全性,并进行统计学分析。结果治疗2周后治疗组和对照组有效率分别为90.00%和75.00%;4周后分别为93.33%和80.77%,疗效差异有统计学意义(P<0.05)。两组均未出现严重不良反应。结论双倍剂量的依巴斯汀治疗慢性自发性荨麻疹效果显著,不良反应轻,安全性高,值得临床应用。 Objective To evaluate the efficacy and safety between double doses of Ebastine and single dose of Ebastine combined with Ketotifen fumarate in treatment of chronic spontaneous urticaria. Methods All the subjects were divided into two groups randomly. The treatment group was prescribed with double doses of Ebastine, the control group was prescribed with single dose of Ebastine and Ketotifen fumarate, and the results were statistically analyzed. Results The results showed that the effective rates were 90. 00% and 75.00% in the treatment and control group respectively after 2 weeks＇ treatment, while the figures were 93.33% and 80. 77% respectively after 4 weeks＇ treatment. There were significant difference （ P 〈 0.05 ） between the two groups about the effective rates. Conclusion A double dose of Ebastine in treatment of chronic spontaneous urticaria is an effective and safe method and it is worthy to spread in clinic.

作者李晓红钱靖吴先伟

机构地区甘肃省人民医院皮肤科

出处《中国医学文摘（皮肤科学）》 2014年第2期67-68,共2页 China Medical Abstracts(Dermatology)

关键词依巴斯汀慢性自发性荨麻疹 Ebastine Chronic spontaneous urticaria

分类号 R758.24 [医药卫生—皮肤病学与性病学]

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参考文献6

1Jurakic Toncic R,Lipozencic J,Marinovic B.Treatment of chronic urticaria [J].Acta Dermatovenerol Croat,2009,17(4):305-322.
2魏义花,张俊花,安荣真,王金良.雷公藤多甙片联合地氯雷他定治疗慢性特发性荨麻疹疗效观察[J].中国皮肤性病学杂志,2010,24(12):1170-1172. 被引量：30
3Gispert J,Antonijoan R,Barhanoj M,et al.Efficacy of ebas-tine,cetirizine,and loratadine in histamline cutaneous challen-ges [J].Ann Allergy Asthma Immnol,2002,89(3):259-264.
4Malik M.Problems of heart rate correction in assessment of drug-induced QT interval prolongation [J].J Cardiovasc Electrophysiol,2001,12(4):411-420.
5Kaplan AP.Clinical practice.Chronic urticaria and angioedema [J].N Engl J Med,2002,346(3):175-179.
6Barbanoj MJ,Antonijoan RM,Gacia-Gea C,et al.A study comparing the inhibitm-y effects of single and repeated oral do-ses of ebastine and fexofenadine against histamine-induced skin reactivity [J].Int Arch Allergy Immunol,2003,132(3):263-267.

二级参考文献10

1Grattan CE,Sabroe BA,Greaves MW.Chronic urticaria[J].J Am Acad Dermatol,2002,46(5):645-657; 657-660.
2Jurakic Toncic R,Lipozencic J,Marinovic B.Treatment of chronic urticaria[J].Acta Dermatovenerol Croat,2009,17(4):305-322.
3Finlay AY,Khan GK.Dermatology Life Quality Index(DLQI)-a simple practical measure for routine clinical use[J].Clin Exp Dermatol,1994,19(3):210-216.
4Augustin M,Ehrle S.Safety and efficacy of desloratadine in chronic idiopathic urticaria in clinical practice:an observational study of 9246 patients[J].J Eur Acad Dermatol Venereol,2009,23(3):292-299.
5Bachert C,Kuna P,Sanquer F,et al.Comparison of the efficacy and safety of bilastine 20 mg vs desloratadine 5 mg in seasonal allergic rhinitis patients[J].Allergy,2009,64(1):158-165.
6Chen X,Murakami T,Oppenheim JJ,et el.Triptolide,a constituent of immunosuppressive Chinese herbal medicine,is a potent suppressor of dendritic-cell maturation and trafficking[J].Blood,2005,106(7):2409-2416.
7Matta R,Wang X,Ge H,et al.Triptolide induces anti-inflammetory cellular responses[J].Am J Transl Res,2009,1(3):267-282.
8钟华,郝飞.荨麻疹的病理生理与临床[J].中华皮肤科杂志,2007,40(10):652-654. 被引量：68
9赵晓辉,席军.雷公藤的药理及临床研究进展[J].实用医技杂志,2003,10(8):958-958. 被引量：6
10郝飞,彭振辉,陈兴平,毕建平,胡敢,刁庆春,闫呼玲,钟华,翁瑞泉,张春明,丁雯刚.地洛他定和氯雷他定治疗慢性特发性荨麻疹多中心双盲对照临床试验[J].中国皮肤性病学杂志,2003,17(4):233-235. 被引量：29