单核细胞趋化蛋白-1与冠心病的相关性研究

Correlation study of MCP-1 with different types of coronary artery disease

目的探讨冠心病患者血浆中单核细胞趋化蛋白-1(MCP-1)水平的影响因素及不同类型冠心病患者血浆中MCP-1表达水平。方法检测急性心肌梗死(AMI)(n=49)、不稳定型心绞痛(UA)(n=49)、稳定型心绞痛和(或)陈旧性心肌梗死(AP+OMI)(n=49)患者及健康对照者(n=49)血浆中MCP-1水平,并同时检测147例冠心病患者血清高敏C-反应蛋白(hs-CRP)水平。结果①血浆中MCP-1水平和hs-CRP呈正相关(r=0.447,P<0.01);MCP-1水平与收缩压(SBP)、体质量指数(BMI)、脂蛋白(a)[LP(a)]、空腹血糖(FBG)呈正相关(r=0.211,P=0.01;r=0.222,P=0.008;r=0.271,P=0.001;r=0.355,P<0.01);MCP-1水平与高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AⅠ(ApoAⅠ)呈负相关(r=-0.227,P=0.009;r=0.268,P=0.002)。②AMI组、UA组、AP+OMI组与对照组比较,血浆中MCP-1水平逐渐降低(1.83±0.36,1.68±0.31,1.61±0.17,1.59±0.59),但只有AMI组与对照组之间比较差异有统计学意义(P=0.001)。结论血浆MCP-1水平与冠心病危险因素相关,提示MCP-1可能作为指示冠心病发生、发展的一个生化指标。

Objective To investigate the influencing factors of plasma MCP-1 levels in patients with coronary artery disease （CAD） and the palsma monocyte chemoattractant protein-1 （ MCP-1 ） expression levels in different types of CAD. Methods Patients with confirmed acute myocardial infarction（AMI） （n = 49 ）, unstable angina（UA） （n = 49）, stable angina and/or old myocardial infarction（AP ± OMI） （n =49） were recruited in the study. Forty-nine healthy controls were also included. The concentration of plasma MCP-1 was measured by enzyme-linked immunoabsorbent assay（ELISA） and the levels of high-sensitivity C- reactive protein（hs-CRP） were detected. Results ①The levels of MCP-1 were positively correlated with hs-CRP, systolic blood pressure （SBP）, body mass index （BMI）, lipoprotein （a） [ LP （a） ], fasting blood glucose （FBG） （ r = 0. 447, P 〈 0.01 ; r = 0. 211,P = 0.01 ;r = 0. 222,P = 0. 008;r = 0.271,P = 0. 001 ;r = 0. 355,P 〈 0.01 ）. The levels of MCP-1 were negatively correlated with high-density lipoprotein-cholesterol （ HDL-C）, apoproteinA I （ ApoA I ） （ r = - 0. 227, P = 0. 009 ; r = 0. 268, P = 0. 002）.②The levels of MCP-1 in the four groups （ AMI group, UA group, AP ＋ OMI group and control group） gradually decreased（ 1.83 ± 0.36,1.68 ± 0.31,1.61 ± 0.17,1.59 ± 0.59）, but only the difference between the AMI group and the control group had significant difference （ P = 0. 001 ）. Conclusion The plasma level of MCP-1 is correlated with some conventional CAD risk factors. MCP-1 may be a biochemical marker for indicating the development of CAD.