急性冠脉综合征患者血清高密度脂蛋白胆固醇、超氧化物歧化酶、游离脂肪酸水平分析

Analysis of Serum High Density Lipoprotein Cholesterol,Super Oxide Dismutase,Non-esterified Fatty Acid Levels in Patients with Acute Coronary Syndrome

目的:探讨高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、游离脂肪酸(NEFA)水平与急性冠脉综合征(ACS)的相关性。方法:选择384例ACS患者为研究组,并选择同期住院的冠状动脉造影示无冠状动脉狭窄的285例非冠心病患者作为对照组,比较两组患者的HDL-C、SOD、NEFA。结果:与对照组比较,研究组HDL-C和SOD水平显著降低(P<0.001),NEFA水平显著升高(JP<0.001);研究组中HDL-C、SOD、NEFA水平均与冠状动脉病变严重程度相关。结论:ACS患者的冠脉病变严重程度和心肌坏死的进展与HDL-C、SOD、NEFA水平密切相关;HDL-C、SOD、NEFA水平的高低可作为预测心肌进一步损伤的重要指标,对冠心病的防治提供重要的临床依据。

Objective：To investigate the levels of high density lipoprotein cholesterol （HDL-C）,super oxide dismutase（SOD） and non-esterified fatty acid（NEFA） in patients with acute coronary syndrome（ACS）. Methods： A total of 384 patients with ACS diagnosed by coronary angiography were selected as research group , and 285 cases admitted to the hospital in the same period with normal coronary angiogram were selected as control group. The HDL-C,SOD and NEFA were compared between the two groups. Results： The levels of HDL-C and SOD in research group were significantly lower than those in control group（P ＆lt; 0.001）.The level of NEFA in research group was significantly higher than that in control group（P ＆lt; 0.001）. In research group, the levels of HDL-C ,SOD and NEFA were related to the severity of the coronary artery stenosis. Conclusion： There is a compact correlation between the severity of coronary artery disease and the progress of myocardial necrosis with the levels of HDL-C、SOD and NEFA in patients with ACS. The levels of HDL-C、SOD and NEFA can be the important indicators to predict the further damage of myocardial, they are provided important clinical evidence for prevention of coronary heart disease.