中等强度有氧运动对难治性高血压合并阻塞性睡眠呼吸暂停综合征患者的影响

The Effect of Moderate Intensity Aerobic Exercise on Patients with Refractory Hypertension and Obstructive Sleep Apnea/Hypopnea Syndrome

目的:探讨中等强度有氧运动对难治性高血压并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的影响。方法:选取难治性高血压并OSAHS患者60例。采用多导联睡眠呼吸监测分析系统进行夜间7 h连续监测。根据睡眠呼吸暂停低通气指数(AHI)将入选患者分为非OSAHS组(A组)、轻度OSAHS组(B组)、中度OSAHS组(C组)及重度OSAHS组(D组),并实行中等强度有氧运动,每周训练5次,共持续8周。比较干预前后血压、AHI及体质量指数(BMI)变化。结果:经中度有氧运动干预8周后,各组患者舒张压、收缩压、BMI均较干预前降低(P<0.05);与干预前相比,干预后A组AHI无明显变化(P>0.05);轻度、中度及重度OSAHS组AHI均降低(p<0.05)。收缩压与AHI、BMI三者间呈正相关,舒张压与AHI相关性不强(r=0.211,P=0.021),舒张压与BMI无明显相关(r=0.046,P=0.617)。结论:中等强度有氧运动能够改善难治性高血压并OSAHS患者血压和通气功能,是难治性高血压合并OSAHS的潜在治疗手段之一。

Objective：To investigate the effect of the moderate intensity aerobic exercise on patients with refractory hypertension and obstructive sleep apnea/hypopnea syndrome （OSAHS）. Methods： 60 patients with refractory hypertension and OSAHS were enrolled in and continuous monitored by using multi-lead sleep monitoring system for 7 h at night. According to the sleep apnea hypoventilation index （AHI）, the cases were divided into non-OSAHS group（group A）, mild OSAHS group（group B）, moderate OSAHS group （group C）and severe OSAHS group （group D）. All cases were carried out moderate intensity aerobic exercise with training 5 times a week and continuously for 8 weeks, and monitoring blood pressure, AHI and BMI before and after the experiment. Results：Compared with before, the diastolic blood pressure （DSP）, systolic blood pressure （SBP） and BMI lower in each group after 8 weeks of moderate intensity aerobic exercise （all P ＆lt; 0.05）. Compared with before, AHI had not obvious change in group A （P ＆gt; 0.05）, but lowered in the other groups （P ＆lt; 0.05）. SBP, AHI and BMI were positively correlated with each other （P ＆lt; 0.05）, DBP was not strong correlation with AHI （r = 0.211, P = 0.211）, DBP had not obvious correlation with BMI （r = 0.046, P = 0.046）. Conclusion： Moderate intensity aerobic exercise can improve blood pressure and ventilation function in patients with refractory hypertension and OSAHS. Moderate intensity aerobic exercise is one of the potential treatments of refractory hypertension and OSAHS.