关于阿尔茨海默病个体化治疗的思考

Considerations about Individualized Treatment of Alzheimer's Disease

阿尔茨海默病(Alzheimer's disease,AD)患者是亟需社会关注的特殊群体,因老年人常罹患多个系统疾病,用药种类繁多,考虑到药物不良反应与相互作用,临床医生在针对老年人用药时,在注重整体性的同时更要关注个体化治疗,辩证施治。药物基因组学是研究基因多态性及其他形式变异引起药物代谢酶、药物转运体和药物作用靶点功能异常,导致药动学和药效学在群体和个体差异的一门科学。它以药物效应及安全性为目标,研究各种基因突变与药效及安全性的关系,掀起了临床用药观念的颠覆性变革,为阿尔茨海默病个体化治疗提供了崭新的视角。

People suffered from Alzheimer＇s disease are absolutely a special group requiring social concerns eagerly .The aged always take various drugs because of affecting multiply system diseases .Considering adverse drug reactions and interactions with each other , the clinicians should pay close attention not only to the integrality but also to the individualization when selecting medicines for the elderly and pursue dialectical treatment .Pharmacogenomics is a science currently used to analyze the dysfunctions of drug-metabolizing enzymes ,drug transporters and targets attributed to gene polymorphism and other forms of variation leading to group and individual differences in pharmacokinetics and pharmacodynamics . Focused on efficacy and security of drugs and their relations with various gene mutations , pharmacogenomics ,has made a profound revolution in concepts of clinical treatments .It provides a new perspective for individualized treatment of Alzheimer＇s disease .