卡孕栓联合催产素预防产后出血210例疗效观察

Clinical effect observation of carboprost combined with oxytocin in prevention of postpartum hemorrhage for 210 cases

目的：探讨卡孕栓联合催产素预防产后出血的疗效.方法：选择足月妊娠阴道分娩210例产妇随机分为实验1组、实验2组和对照组,每组70人.实验1组（卡孕栓直肠给药组）于胎儿娩出后立即将卡孕栓1 mg置入直肠内;实验2组（卡孕栓舌下含服组）于胎儿娩出后立即舌下含服卡孕栓1mg,两组用药的同时肌肉注射催产素10u.对照组（单纯催产素组）于胎儿前肩娩出后肌肉注射催产素20u.比较三组第3产程时间、产后2h出血量及产后24 h出血总量和产后出血发生率.结果：实验1组和实验2组产妇第3产程时间、产后2h出血量及产后24 h出血总量差异无统计学意义（P＞0.05）.实验1组、实验2组与对照组产妇的第3产程时间、产后2h出血量及产后24h出血总量、产后出血发生率差异有统计学意义（P＜0.05）.结论：应用卡孕栓联合催产素具有预防产后出血作用,值得临床推广.

ObjectiveTo investigate effects of carboprost combined with oxytocin in prevention of postpartum hemorrhage.Methods：210 cases of vaginal delivery with full-term pregnancy were randomly divided into experimental group 1 （70 cases）, experi-mental group 2 （70 cases） and control group （70 cases）. For experimental group 1 （rectal administration group）, 1mg carboprost wasgiven into the rectum immediately after the fetus was delivered; for experimental group 2 （sublingual group）, 1mg carboprost was givenunder the tongue immediately after the fetus was delivered, and 10u oxytocin was also given to the two groups through intramuscular in-jection. Whereas, 20u oxytocin was given to control group （single oxytocin group） through the intramuscular injection after the fetus＇santerior shoulder was delivered. The time of the third stage of labor, the amounts of 2h postpartum hemorrhage and 24h postpartumhemorrhage, and the incidence rates of the postpartum hemorrhage of the three groups were compared. Results： There were no statisti-cal differences in the time of the third stage of labor and the amounts of 2h postpartum hemorrhage and 24h postpartum hemorrhage be-tween experimental group 1 and experimental group 2 （P〉0. 05）. However, there were the statistical differences in the time of thethird stage of labor, the amounts of 2h postpartum hemorrhage and 24h postpartum hemorrhage and the incidence rates of the postpar-tum hemorrhage between experimental group 1 and control group and between experimental group 2 and control group （P〈0. 05）. Con-clusions： Carboprost combined with oxytocin can prevent the postpartum hemorrhage and is worthy of promotion.