艾司西酞普兰与氟西汀改善首发抑郁症患者认知损害的疗效研究

Study of effects of escitalopram and fluoxetine on cognitive impairment improvement for patients with first-episode depression

目的:比较艾司西酞普兰与氟西汀对首发抑郁症患者认知功能的影响。方法:选取抑郁症患者60例,随机分为艾司西酞普兰治疗组(A组)和氟西汀治疗组(B组)各30例,在治疗前和治疗8周后,分别对两组患者进行认知测试及汉密尔顿抑郁量表评定。结果:治疗8周后,A、B两组患者的抑郁评分与基线比均明显下降(P<0.01),且A组显效率、有效率均高于B组(P<0.05)。治疗后,A、B两组患者的P2、N2、P3潜伏期及反应时间明显低于治疗前(P<0.01),P2、N2、P3波幅明显高于治疗前(P<0.01)。A组较B组P3潜伏期、反应时间明显缩短,且N2、P3波幅A组高于B组(P<0.01)。结论:在改善首发抑郁症认知功能方面,艾司西酞普兰优于氟西汀,且艾司西酞普兰疗效明显、耐受性更好。

ObjectiveTo compare effects of escitalopram and fluoxetine on cognitive function improvement for patients with infirst-episode depression. Methods：60 patients meeting the criteria of ICD-10 for depression were enrolled and divided into escitalo-pram treatment group （A, 30 cases） and fluoxetine treatment group （B, 30 cases）. The cases were assessed with Hamilton depressivescale （HAMD） and measured with P300 before and 8 weeks after the treatment. Results： 8 weeks after the treatment, the HAMDscores of the two groups both obviously decreased （P〈0. 01）, and the obvious effective rate and effective rate of A group were higherthan those of B group （P〈0. 05）. The latency and reaction time of P2, N2, and P3 of A and B groups after the treatment were signifi-cantly prolonged than those before the treatment, and the amplitude of P2, N2 and P3 increased compared with those before the treat-ment （P〈0. 01）. Moreover, the latency and the reaction time of P3 in A group were reduced than those of B group, the amplitude ofN2 and P3 in A group were higher than those of B group （P〈0. 01）. Conclusions： The effects of escitalopram on cognitive impairmentimprovement for the patients with first-episode depression would be better than those of fluoxetine. Further, the curative effect of es-citalopram is obvious and the tolerance is better.