导管溶栓术治疗急性下肢深静脉血栓形成的疗效观察

Observation of clinical effects of catheter-directed thrombolysis in treatment of acute deep venous thrombosis of lower limbs

目的：探讨导管溶栓术治疗急性下肢深静脉血栓形成的临床效果及安全性.方法：选择82例下肢深静脉血栓形成患者,全部患者均在抗凝的同时配合导管溶栓治疗,观察患者的临床疗效及不良反应情况.结果：全组患者溶栓后症状明显改善,下肢肿胀消退,肺部症状缓解.溶栓前大腿周径差（5.83±0.52）cm,溶栓前小腿周径差（4.90±1.27）cm;溶栓后大腿周径差（2.66±0.82）cm,溶栓后小腿周径差（1.90±0.53）cm.所有患者均无严重并发症.82例患者获随访,随访6～12个月,平均（8.1±1.3）个月.无一例出现血栓再发.结论：导管溶栓术治疗下肢深静脉血栓形成,临床操作简单,治疗效果明显,并发症少,能显著改善患者的生活质量,值得临床推广.

ObjectiveTo analyze clinical effects and safety of catheter-directed thrombolysis in treatment of acute deep venousthrombosis in lower limbs. Methods：From February 2011 to February 2012, 82 patients with deep vein thrombosis in the lower limbswere selected and treated with anticoagulation therapy and catheter-directed thrombolysis therapy in our hospital. The clinical effectsand adverse reactions were observed. Results： All patients showed significantly improved symptoms after the thrombolysis, includingthe disappeared leg swelling and alleviated pulmonary symptoms. Before the thrombolysis, thigh circumference difference was （5. 83依0. 52） cm and leg circumference difference was （4. 90依1. 27） cm; however, after the thrombolysis, the thigh circumference differenceand leg circumference difference were （2. 66依0. 82） cm and （1. 90依0. 53） cm, respectively. No patients had serious complications.The involved 82 patients were followed up for 6-12 months with an average of （8. 1依1. 3） months. Thrombosis recurrence was not ob-served in all cases. Conclusions： The catheter-directed thrombolysis is a simple-operated and effective therapy for deep venous throm-bosis in the lower limbs with a few complications, and it can significantly improve the patient＇s quality of life and deserves further appli-cation.