中性粒细胞与淋巴细胞比值对结肠癌肝转移射频消融术后肿瘤复发的影响

Neutrophil-lymphocyte ratio as a prognostic factor after radiofrequency ablation for liver metastasis of colon cancer

目的:探讨外周血中性粒细胞与淋巴细胞比值(NLR)对结肠癌肝转移射频消融术后肿瘤复发的影响。方法:回顾性分析98例行射频消融术的结肠癌肝转移患者临床资料。单因素分析术前最大肿瘤直径、肿瘤数目、结肠癌病理分期、CEA水平、术前和术后NLR等对术后无瘤生存率的影响。有统计学意义的影响因素进入Cox回归模型行多因素分析。结果:1、3、5年的无瘤生存率分别为66.3%、28.6%和17.3%。单因素分析显示术前NLR≥2.5和术后NLR升高影响术后无瘤生存率。NLR<2.5和NLR≥2.5的患者1、3、5年无瘤生存率分别为77.4%、35.8%、22.6%和53.3%、20.0%、11.1%(P=0.044)。术后NLR升高和不升高的患者1、3、5年无瘤生存率分别为52.3%、17.1%、8.6%和73.0%、34.9%、22.2%(P=0.022)。Cox回归分析显示仅术后NLR升高为影响结肠癌肝转移射频消融术后复发的独立危险因素(P=0.029)。结论:术前NLR≥2.5及术后NLR升高的结肠癌肝转移患者射频消融术后肿瘤复发的风险增加。

Objective：To investigate the effect of PeriPheral blood neutroPhil - lymPhocyte ratio on the tumor re-currence of liver metastasis of colon cancer after radiofrequency ablation. Methods：To retrosPectively analyze 98 cases of radiofrequency ablation of liver metastasis of colon cancer. Univariate analysis was Performed on PreoPerative maxi-mal tumor diameter,tumor number,colon cancer staging,Pathological effects of CEA levels,PreoPerative and PostoPer-ative NLR with the PostoPerative disease - free survival rate,and then by multivariate analysis of Cox regression mod-el. Results：1,3,5 years disease - free survival rates were 66. 3% ,28. 6% and 17. 3% resPectively. Single factor a-nalysis showed PreoPerative NLR≥2. 5 and NLR after the oPeration affected increased PostoPerative disease - free survival rate. NLR ﹤ 2. 5 and NLR≥2. 5 were 1,3,5 years disease - free survival rates were 77. 4% ,35. 8% ,22. 6%and 53. 3% ,20. 0% ,11. 1% resPectively（P = 0. 044）. Patients with elevated NLR after oPeration and no increased 1,3,5 years disease - free survival rate was 52. 3% ,17. 1% ,8. 6% and 73. 0% ,34. 9% ,22. 2% resPectively（P =0. 022）. Cox regression analysis showed that only NLR elevation after oPeration was indePendent risk of recurrence of colon cancer liver metastasis after radiofrequency catheter ablation（P = 0. 029）factor. Conclusion：PreoPerative NLR≥2. 5 and NLR PostoPerative elevated liver metastasis of colon cancer after radiofrequency ablation in Patients were with an increased risk of tumor recurrence.