心外膜脂肪组织厚度与急性心肌梗死的关系

Correlation Between Epicardial Adipose Tissue and Acute Myocardial Infarction

目的心外膜脂肪组织（EAT）与冠状动脉斑块的稳定性密切相关，本研究旨在探讨超声测量ETA厚度与急性心肌梗死（AMI）的关系。资料与方法选取38例AMI患者作为AMI组；40例疑似AMI，且冠状动脉造影结果正常的患者作为对照组。所有患者均行超声心动图检查，测量舒张期右心室游离壁前方的EAT厚度，对两组的EAT值进行比较。结果AMI组的EAT厚度显著高于对照组，差异有统计学意义（t=-6．471，P〈0．01）。ETA厚度与年龄、体重指数、低密度脂蛋白胆固醇呈呈正相关（r=0．284、0．253、0．132，P〈0．05）：EAT厚度与高密度脂蛋白胆固醇呈负相关（r=-0．116，P〈0．05）。ROC曲线示EAT厚度为7．0mm时，敏感度为81．6％，特异度为67．5％，ROC曲线下面积为0．847，95％C10．76～0．93（P〈0．01）。结论AM!患者的EAT厚度显著增高，ETA显著增厚可能是AMI的一个危险因素。

Purpose To explore the correlation between epicardial adipose tissue （EAT） measured by echocardiography and acute myocardial infarction （AMI） as EAT is closely related with instability of coronary artery plaque. Material and Methods Thirty-eight patients with AMI were taken as AMI group and 40 patients with suspected AMI whose coronary arteriongraphy presented normal were taken as control group. All patients underwent echocardiography, and their thickness of EAT in the front of free ventricular wall was measured and compared between the two groups. Results The EAT thickness in AMi group was significantly higher than that in the control group （difference with statistic significance, t=6.471, P〈0.01）. EAT was positive correlated with age （r-0.284, P〈0.05）, body mass index （r=0.253, P〈0.05） and low-density lipoprotein （r=0.132, P〈0.05）, but it showed negative correlation with high-density lipoprotein （r=- 0.116, P〈0.05）. The ROC analysis demonstrated that the sensitivity and reached specificity were 81.6% and 67.5% when EAT thickness was 7.0 mm, and that area under the curve was 0.847 （95% CI 0,76-0.93, P〈0.01）. Conclusion EAT thickness grows dramatically in patients with AMI, which suggests a significant increase of EAT may be a risk factor for AMI.