功能性磁共振成像应用于穴位脑区功能效应的研究进展

Application of functional magnetic resonance imaging in acupoint functional significance of encephalic region

收集中国知网(CNKI)、万方数据库等应用功能性磁共振成像(fMRI)技术探讨针刺穴位脑区功能效应的研究文献,分别从生理及病理状态下的单穴、双穴及多穴配伍研究现状进行分析和评论。结果表明针刺穴位可特异性地激活相应的脑区;针刺不同的穴位,所激活的脑区是有差异的。然而目前已开展的研究中仅以单穴、双穴及三穴为主,缺乏对临床常见穴位配伍效应的观察;且由于操作规程、针刺补泻手法、穴位刺激强(深)度、留针时间等因素的不统一,客观上影响了试验结果的可靠性。因此,在今后的研究中需建立一套统一规范的操作规程,并严格控制可能影响试验结果的偏倚因素,尽量以患者为研究对象开展研究,以进一步探讨其中枢效应机制。

Literatures of study on acupoint functional effect of encephalic region with functional magnetic reso- nance imaging （fMRI） are collected from the database of China National Knowledge Information （CNKI） and Wan fang database. Analysis and comments are made respectively from the status quo of studies on combination of single acupoint, two acupoints and multiple acupoints under both physiological and pathological conditions. The results show that the corresponding encephalic regions can be specifically activated by acupuncture. And different regions can be activated by different acupoints. However, studies on single acupoint, two acupoints and three acu- points are the major researches carried out at present. It is still lack of observation on effect of commonly-used combinations in clinic. Moreover, the reliability of the research results are also affected by disunity of operations protocol, reinforcing or reducing manipulations, intensity or depth of stimulation and duration of needling reten- tion. Therefore, it is necessary to establish a unified and standard operation protocol to strictly control the bias factors which may affect the result of research in the future, and take patients as the study target as much as possi- ble, so as to further explore the central effect mechanism.