摘要
目的探讨泪腺炎患者血清中白细胞介素4（interleukin-4，IL-4）、IL-17和γ-干扰素（γ-interferon，γ-IFN）的含量及意义。方法收集2012年10月到2013年7月于我院诊断为泪腺炎的31例患者的炎症期及炎症缓解期血清样本各31份，另收集同期正常体检血清标本32份为正常对照组。采用酶联免疫吸附试验（ELISA）检测泪腺炎患者炎症期及炎症缓解期和正常血清中IL-4、IL-17、γ-IFN的含量，并进行对比分析。结果泪腺炎患者炎症期血清中IL-4、IL-17和γ-IFN3种因子含量分别为945．96～1594．28ng·L^-1、178．42，300．50ng·L^-1和371．56～432．08ng·L^-1，较炎症缓解期（分别为604．06～987．33ng·L^-1、106．60～156．78ng·L^-1和175．86～241．04ng·L^-1）及正常对照组（分别为604．84～1293．06ng·L～、108．88～164．36ng·L^-1和166．00～191．52ng·L^-1）显著增高（均为P〈0．05）；泪腺炎患者炎症缓解期与正常对照组血清中3种因子含量相比，差异均无统计学意义（均为P〉0．05）。结论以IL-4、IL-17和γ-IFN为主要代表的Th1、Th17及Th2细胞可能参与了泪腺炎病变过程，并可在血清中检测到变化，该疾病是与全身免疫相关的。
Objective To investigate the contents and significances of interleu- kin-4（IL-4） ,IL-17 and γ-interferon（γ-IFN） in serum of dacryoadenitis patients. Meth- ods A total of 31 dacryoadenitis patients with their data and blood samples in inflam- mation and remission stage were collected in our hospital from October 2012 to July 2013 ,then another 32 normal cases with their blood samples were collected as normal group. The content of IL-4, IL-17 and γ-IFN in serum of patients were detected by ELISA. Results IL-4, IL-17 and γ-IFN in serum levels in inflammatory stage of dacryoadenitis patients [ 945. 96 - 1594. 28 ng · L-1 , 178. 42 - 300. 5 ng · L-1 and 371.56 -432.08 ng · L-1 were significantly higher than those of remission E 604.06 - 987.33 ng · L-1 ,106.6 - 156.78 ng · L-1 and 175.86 -241.04 ng · L-1 ] and normal con- trol group[604. 84 - 1293.06 ng · L-1, 108. 88 - 164. 36 ng · L-1 and 166 - 191. 52 ng · L - 1 ] （ all P 〈 0.05 ）, there was no statistical significance between inflammation re- mission stage of dacryoadenitis patients and normal control group （ all P 〉 0.05 ）. Con- clusion Th1 and Th17 Th2 ceils which were represented by IL-4 ,IL-17 and γ-IFN may participate in the lacrimal gland inflammation process, and can be detected the changes in serum, the disease is associated with systemic immune.
出处
《眼科新进展》
CAS
北大核心
2014年第5期471-473,共3页
Recent Advances in Ophthalmology
