新疆汉族与维吾尔族女性原发性骨质疏松患者降钙素受体基因多态性的对比研究

Comparative study on calcitonin receptor gene polymorphism in Xinjiang Han and Uygur female patients with primary osteoporosis

目的探讨新疆地区汉族及维吾尔族人群降钙素受体基因型频率分布及其与原发性骨质疏松症的关系。方法女性原发性骨质疏松患者100例(OP组),其中汉族50例(汉族OP组)、维吾尔族50例(维族OP组);体检健康无骨质疏松女性80例(对照组),其中汉族40例(汉族对照组)、维吾尔族40例(维族对照组)。检测并分析各组降钙素受体基因核苷酸序列1377位点C/T多态性分布。结果各组降钙素受体基因1377位点C/T多态性位点等位基因频率分布均符合Hardy-Weinberg定律;汉族OP组与汉族对照组、维族OP组与维族对照组降钙素受体基因型及等位基因频率比较差异均无统计学意义(P>0.05),汉族组降钙素受体基因型及等位基因频率与维族组比较差异有统计学意义(P<0.05)。结论降钙素受体基因多态性可能不是影响骨质疏松发病的重要因素;新疆地区汉族与维吾尔族女性人群降钙素受体基因核苷酸序列1377bp处多态性存在民族差异。

Objective To observe the relationship of calcitonin receptor genotype frequency distribution with primary osteoporosis in Han and Uygur populations. Methods One hundred female patients with primary osteoporosis （OP group） including 50 Han and 50 Uygur patients, and another 80 healthy volunteers including 40 Han and 40 Uygur individuals were determined the distribution of 1377-bp C/T single nucleotide polymorphism in calcitonin receptor gene. Results The distribution of 1377-bp C/T single nucleotide polymorphism in calcitonin receptor gene was coincident with the Hardy-Weinberg law. There were no significant differences in calcitonin receptor genetype and allele frequency between Han OP group and Han control group, and between Uygur OP group and Uygur control group （P^0.05）, and there were significant differences between Han group and Uygur group （P〈0.05）. Conclusions Calcitonin receptor gene polymorphism might not be an important factor of osteoporosis. There is a race difference in 1377-hp C/T single nucleotide polymorphism of calcitonin female receptor gene between Han and Uygur female patients.