重度子疒间前期孕妇凝血指标水平变化

Changes of coagulation parameters in patients with severe preeclampsia

目的分析重度子疒间前期孕妇凝血指标水平的变化,探讨凝血功能异常与病情程度的关系。方法重度子疒间前期孕妇(观察组)、正常待产孕妇(对照组)各64例,检测并比较2组凝血酶原时间(prothrombin time,PT)、PT百分活动度、凝血酶原国际标准化比值(International Normalized Ratio,INR)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、纤维蛋白原(fibrinogen,FIB)、凝血酶时间(thrombin time,TT)、D-二聚体(D-dimer,DD)、血小板计数;采用Shapiro-Wilk检验2组血小板计数分布范围。结果 2组PT、PT百分活动度、INR、FIB、TT、D-D水平比较差异有统计学意义(P<0.05),APTT、血小板计数比较差异无统计学意义(P>0.05);观察组血小板计数分布范围较对照组增大,但差异无统计学意义(P>0.05)。结论重度子疒间前期孕妇凝血功能除出现异常高凝外,还可能合并继发性纤溶亢进。

Objective To analyze the changes of coagulation parameters in patients with severe preeclampsia in order to explore the relationship between coagulation abnormalities and the severity of severe preclampsia. Methods The prothrombin time （PT）, PT percentage activity （PT%）, International Normalized Ratio （INR）, activated partial thromboplastin time （APTT）, fibrinogen （FIB）, thrombin time （TT）, D-dimer and platelet count were detected in 64 patients with severe preeclampsia group （observation group） and 64 prepartal women （control group）. The normal distribution of platelet was examined by Shapiro-Wilk test in two groups. Results There were significant differences in PT, PTT, INR, FIB, TT and D-dimer （P〈0.05）, and no significant differences in APTT and piatelet count （P〉0.05） between two groups. The normal distribution of platelet was larger in observation group than that in control group, but there was no significant difference （P〉0.05）. Conclusions Severe preeclampsia may have hypercoagulabiiity, also would be complicated with secondary hyperfibrinolysis.