乌鲁木齐市1310例住院心房颤动患者的临床分析

The clinical analysis of atrial fibrillation of 1 310 in patients in Urumqi of China

目的 调查乌鲁木齐市心房颤动（房颤）患者的临床特征与治疗现状.方法 对2008年1月-2012年12月乌鲁木齐市12家医院诊断的房颤患者的病历资料进行回顾性分析.结果 共纳入1 310例房颤住院患者,男女比例1.39：1,年龄为（64.8±3.3）岁,61～ 70岁与71～80岁两个年龄组所占比例最多,分别为26.5％（347/1 310）和27.6％（361/1 310）.阵发性房颤患者心功能Ⅰ～Ⅱ级比例较其他类型房颤患者高,为75.2％,持续性房颤患者心功能Ⅲ～Ⅳ级比例较高,为31.0％.房颤患者合并主要临床疾病依次为高血压（49.2％）、冠心病（38.5％）、糖尿病（20.1％）.阵发性房颤患者无论是胺碘酮复律或是射频消融维持窦性心律的成功率均高于慢性房颤者（44.8％比29.9％,87.5％比68.9％,P值均＜0.05）.75.7％房颤患者接受抗栓治疗,使用阿司匹林、华法林及利伐沙班等其他新型抗凝药物患者CHA2DS2评分的差异有统计学意义[2（1,3）比3（2,4）比3（2,5）,P＜0.05],三组间脑梗死发生率比较差异有统计学意义（6.3％比23.8％比30.2％,P＜0.05）.结论 乌鲁木齐市房颤住院患者在年龄、性别、相关疾病分布、房颤类型、卒中及治疗等流行病学特点与国内外报道基本相似.

Objective To investigate the clinical features and current therapy of atrial fibrillation （AF） of inpatients in Urumqi,China.Methods The clinical data of inpatients diagnosed with AF from January,2008 to December,2012,in 12 hospitals in Urumqi were retrospectively analyzed.Results Totally 1 310 AF inpatients were enrolled in this study with the age of （64.8 ±3.3） years old and a men to women ratio of 1.39.Most patients were in age groups of 61-70 years （26.5％） and 71-80 years （27.6％）.More patients with paroxysmal AF were at cardiac function class Ⅰ-Ⅱ （75.2％）,while more patients with persistent AF were at cardiac function class Ⅲ-Ⅳ （31.0％） （both P values ＜ 0.05）.The most common co-morbidities of AF were hypertension （49.2％）,coronary heart disease （38.5％）,diabetes mellitus （20.1％）.Compared with patients of chronic AF,the patients of paroxysmal AF had higher success rates in amiodarone conversation and sinus rhythm maintenance after ablation （44.8％ vs 29.9％,87.5％ vs 68.9％,P values ＜ 0.05）.Among the 1 310 inpatients,992 patients （75.7％） received antithrombotic therapy.There were statistically significant differences in CHA2DS2 score and incidence rate of cerebral infarction among patients receiving aspirin,warfarin or rivaroxaban/other anticoagulation drugs [2 （1,3） vs 3 （2,4） vs 3 （2,5） and 6.3％ vs 23.8％ vs 30.2％,both P values ＜0.05].Conclusion Our results of AF inpatients＇ age,gender,related disease distribution,AF types,incidence of stoke,therapeutic and epidemiological features are in accordance with the domestic and abroad reports.