普拉洛芬滴眼液对白内障超声乳化术后黄斑囊样水肿预防作用的研究

Study of Pranoprofen Eyedrops on Prophylaxis of Cystoid Macular Edema after Cataract Phacoemulsification

目的：研究普拉洛芬滴眼液对白内障超声乳化联合人工晶体植入术后黄斑囊样水肿的预防作用，探讨普拉洛芬滴眼液在白内障超声乳化联合人工晶体植入术后的临床应用价值。方法选取2013年3月～2013年6月在我院行白内障超声乳化联合人工晶体植入术、无并发症的65例（80眼）年龄相关性白内障患者，并随机分成治疗组和对照组，每组40眼。治疗组患者术后妥布霉素地塞米松滴眼液＋普拉洛芬滴眼液合用2周，单独使用普拉洛芬滴眼液2周，对照组患者术后使用妥布霉素地塞米松滴眼液4周。结果两组的术后症状和体征无明显差异，在术前、术后3个月时两组均行光学相干断层扫描（ OCT）检查，发现治疗组40眼中有2眼发生黄斑囊样水肿（5％），对照组中有5眼发生黄斑囊样水肿（12．5％），差异有统计学意义（P＜0．01）。结论普拉洛芬滴眼液对白内障超声乳化联合人工晶体植入术后黄斑囊样水肿的发生有预防作用。

Objective To study the prophylaxis effect of pranoprofen eyedrops on cystoid macular edema （ CME） after cataract phacoemulsification with intraocular lens implantation .To investigate the value of clinical applica-tion of pranoprofen eye drops after cataract phacoemulsification .Methods Eighty eyes from 65 age-related cataract pa-tients undergone cataract phacoemulsification and intraocular lens implantation from Mar .2013 to Jun.2013 were en-rolled and assigned to the trial group （ n=40 ） and the control group （ n=40 ） randomly ,excluding the subjects with com-plications.After uneventful phacoemulsification and IOL implantation ,the patients in trial group were treated with topical treatment with Tobramycin and Dexamethasone combined with Pranoprofen for 2 weeks and Pranoprofen only for 2 weeks.The patients in control group were treated with topical treatment with Tobramycin and Dexamethasone only for 4 weeks.Results There were no significant differences in symptoms and signs after surgey between two groups .Optical co-herence tomography （ OCT） were performed before cataract surgery and 3 months after cataract phacoemulsification .Two eyes（5%） developed CME in the trial group and 5 eyes（12.5%） in the control group.There were significante differ-ences between 2 groups（P〈0.05）.Conclusion Pranoprofen eye drops reduced the occurrence of CME after cataract phacoemulsification .It is worthy of clinical wide application after cataract surgery .