人乳头状瘤病毒DNA甲基化与宫颈癌的研究进展

HPV DNA methylation and cervical cancer:literature review

持续性高危型人乳头瘤病毒（human papillomavirus，HPV）感染是导致宫颈癌的主要原因。近年来，宫颈脱落细胞学检测和HPV的检测成为宫颈癌筛查的重要手段，但宫颈脱落细胞学具有较高的假阴性率，HPV检测虽然有助宫颈脱落细胞学未明确诊断意义的不典型鳞状上皮内细胞的分类，但只有很少一部分HPV感染者的宫颈病变发展成宫颈癌，HPV检测不能确定HPV感染者是否处于宫颈病变的进一步进展人群。

To summarize the association between HPV DNA methylation and cervical cancer by reviewing pub- lished literatures. Literatures containing keywords ＂ HPV DNA, methylation, cervical cancer, cervical dis- ease ＂ from Jan 2002 to Dec 2012 were retrieved by searching Medline and ＂ Chinese Biomedical Literature Database＂,＂ Chinese Science and Technology Academic Journal＂,＂ China Academic Journal＂,＂ WanFang DATA＂ . Inclusion criteria： independent case-control and or cohort studies with research questions and meth- ods focused on HPV DNA methylation and cancer or other cervical lesions, documents having effective statis- tical indicators and with expressible results and corresponding statistical indicators. Exclusion criteria： review papers, no control and repeated reports or incomplete original data. A total of 865 English and 12 Chinese pub- lications were retrieved. Based on the above inclusion and exclusion criteria, only 24 English and 1 Chinese pa- pers were included for further analysis. It suggested a positive correlation between HPV DNA methylation at CpG sites and the cervical cancer and precancerous lesions especially between the L1 gene methylation and CIN2＋lesions while no consistent conclusions can be made between URR gene methylation and CIN2 ＋ le- sions. HPV rnethylation may be related to the progression of cervical cancer.