肺黏液表皮样癌靶向治疗的研究进展

New Developments in Targeted Therapy of Pulmonary Mucoepidermoid Carcinoma

肺黏液表皮样癌是非小细胞肺癌的一种少见类型,对传统化疗和放疗缺乏特异性。由于其发病率较低,且缺乏大型的临床随机对照研究,因此对其最佳的治疗标准尚未确立。近年来,随着肿瘤生物学和细胞生物学的发展,分子靶向治疗作为一项极具潜力的新方法已经逐渐成为肺黏液表皮样癌临床治疗的一部分。本文对其靶点和作用机制的研究进展进行了综述。

Pulmonary mucoepidermoid carcinoma （PMEC） is rare and survival does not appear to be improved by tra- ditional chemotherapy and radiotherapy. Because of the low incidence and lack of large randomized studies, optimal therapy for PMEC has not yet been established. With the development of tumor and cell biology, molecular targeted therapy as a potentially new approach has gradually become part of the clinical treatment of PMEC. We reviewed the progress of research on PMEC, focu- sing on its therapeutic target and mechanism of action.