糖肾化浊方治疗Ⅳ期糖尿病肾病的疗效分析

Effects of tang shen hua zhuo recipe in patients with Ⅳ stage of Diabetic Nephropathy

目的观察糖肾化浊方治疗Ⅳ期糖尿病肾病的临床疗效。方法 100例Ⅳ期糖尿病肾病患者随机分为治疗组和对照组,各50例。治疗组口服糖肾化浊方免煎颗粒,每日2次,并联合厄贝沙坦150mg/d;对照组口服厄贝沙坦150mg/d。观察尿微量白蛋白排泄率,同时测定空腹血糖、糖化血红蛋白、血肌酐、尿素氮、血脂等。结果按方案完成98例,治疗组48例,对照组50例。6个月后,治疗组尿微量白蛋白排泄率、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇均优于对照组(P<0.01)。结论糖肾化浊方能有效改善Ⅳ期糖尿病肾病。

Objective To observe the effects of Tang shen hua zhuo Recipe （TSHZR） in the treatment of patients from IV stage of diabetic nephropathy. Method One hundred patients with Ⅳ stage DN were randomly assigned into the control group （n=50）treated by irbesartan alone and the treated group （n= 50）treated by TSHZR combined with irbesartan for 6 months. All patients received diabetes fundamental drug. The urine albumin excretion rate was used as the assessment index of therapeutic effect, and fasting blood glucose, HbA1 c, serum creatinine, blood urea ni- trogen and lipid profiles ,were examined as well. Result According to the protocol complete observation of 98 cases, 48 cases in treatment group and control group of 50 cases. The clinical control rates were significantly differences observed among the two groups. After treatment the urine albumin excretion rate, the levels of triglyceride, total cho- lesterol and low density lipid cholesterol in treatment group all significantly lower than control group （ P〈0.01 ）, and the levels high density lipid cholesterol in treatment group significantly higher than control group （ P〈0.01 ）. Conclusion The results show that TSHZR can effectively improve Ⅳ stage of diabetic nephropathy, compared with irbesartan has more advantages.