鼻咽癌放疗前后中医证型分布及其演变规律的研究

Study on the syndrome differentiation of TCM in nasopharyngeal carcinoma

目的观察分析鼻咽癌放疗前后各阶段的中医证型分布,总结其中医证型的演变规律。方法选取本院96例鼻咽癌住院患者的临床资料,总结分析患者的临床症状特点,根据中医辩证学的特点进行归纳分类,并探索其演变规律。结果鼻咽癌患者放疗前后的证型可分为4大类,即痰湿证、血瘀证、热毒证及肾虚证。但4种证候群在放疗过程中具有不同分布情况。放疗前,痰湿证最高48.0%;放疗中,热毒证最高占43.7%;放疗后,热毒证、肾虚证较高,分别为31.2%、26%;结论鼻咽癌患者在放疗前后的各阶段具有不同的分布特点,主要可分为4大类。表征该病的关键致病因子为痰、瘀、热、虚。

Objective To observe the differentiation of syndromes character before and after radiotherapy in patients with nasopharyngeal carcinoma, and summarize the evolvement law of syndromes character. Methods 96 cases of patients diagnosed with the nasopharyngeal carcinoma were selected for the retrospective analysis. The clinical characteristics were summarized and analyzed.These data were concluded and classified according to Chinese medicine dialectics for investigation of the evolvement law.Results The syndromes of patients were divided into four groups, namely the phlegm-dampness syndrome, the blood stasis syndrome, the heat-toxin syndrome and the kidney-deficiency syndrome. Four syndromes in the each stage of radiotherapy showed the different distribution.Before radiotherapy, the phlegm-dampness syndrome accounted for the maximal proportion with 48.0%.During radiotherapy, the proportion of the heat-toxin syndrome was the largest for 43.7%.After radiotherapy,the heat-toxin syndrome and the kidney-deficiency syndrome were higher by 31.2% and 26%, respectively.Conclusion The syndromes character of the nasopharyngeal carcinoma in the different stages could be divided into four groups.The key virulence factors include phlegm ,blood stasis ,heat and deficiency.