视黄醇结合蛋白4与动脉粥样硬化关系的研究

A study on correlation between retinol-binding protein 4 and atherosclerosis

目的探讨血浆视黄醇结合蛋白-4(RPB4)与动脉粥样硬化(AS)的关系。方法 90例研究对象行颈动脉超声测量颈动脉内膜中层厚度(IMT),根据IMT<1.Omm与≥1.Omm分为IMT正常组和IMT增厚组,测定血浆RPB4水平。结果 IMT增厚组的总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、高敏C反应蛋白(hsCRP)、RBP4及冠心病、2型糖尿病、脑动脉硬化患病率均显著高于IMT正常组,差异有显著性。相关分析显示血浆RBP4与腰围、体重指数、甘油三酯、TC、LDL-c、HbAlc、HOMA-IR、hsCRP、IMT呈正相关。结论血浆RBP4在As的发生、发展过程中起到一定作用。

Objective To investigate the correlation between plasmal retinol-binding protein 4 （ RBP4 ） levels and atherosclerosis （AS）. Method According to carotid intima-media thickness（IMT）, 90 subjects were divided into two groups：the normal IMT group and the thickened IMT group. Plasmal RBP4 levels were measured by ELISA. Result Plasmal TC, LDL, HbA1c, FINS, HOMA-IR, hsCRP, RBP4 levels and the morbidity rate of coronary heart disease, type 2 diabetes mellitus and cerebral arteriosclerosis in the thickened IMT group was significantly higher than those in the normal IMT group, Plasmal RBP4 level was positively correlated with Waist, BMI, TC, TG, LDL, HbA1c, HOMA-IR, hsCRP, IMT. Conclusion Elevated RBP4 levels might affect the delevopment of AS.