摘要
目的:评价临床药师干预甲状腺手术患者围术期抗菌药物合理性的效果。方法:分别抽取某三甲医院2010年9月至2011年8月(干预前)和2011年9月至2012年8月(干预后)的甲状腺手术出院患者病历各90份,对围术期预防性应用抗菌药物的合理性进行比较。结果:经临床药师干预,该院甲状腺手术患者围术期抗菌药物预防使用率由干预前的96.67%下降到干预后的16.67%,差异有统计学意义(P=0.000,<0.05);用药适应证、药物选择、用法用量、术前用药时机、用药疗程、联合用药等指标合理率均显著提高(P<0.05)。干预前后切口感染率均为0,差异无统计学意义(P>0.05),手术前后体温变化及外周血白细胞计数差异无统计学意义(P>0.05)。结论:临床药师对甲状腺手术围术期预防应用抗菌药物的干预可行且有效,可对Ⅰ类切口围术期合理预防用药起到积极的作用。
OBJECTIVE：To evaluate the outcome of clinical pharmacists＇ intervention on perioperative antibiotic use in patients undergoing thyroid surgery.METHODS：The medical records of patients undergoing thyroid surgery between Sept.2010 and Aug.2011 （before intervention,90 cases） versus between Sept.2011 and Aug.2012 （after intervention,90 cases） in a three-A level hospital were analyzed regarding the rationality in antibiotic use.RESULTS：After clinical pharmacist＇s intervention,the rate of antibiotic use declined statistically from 96.67％ to 16.67％ （P=0.000,＜ 0.05）; moreover,the perioperative use of prophylactic antibiotics was improved significantly in respect of indications,choice of antibiotics,dosage and usage,preoperative administration time and duration and drug combination etc （P ＜ 0.05）; the wound infection rates before and after interventions were 0 （P＞0.05） ; the differences before and after surgery in body temperature and peripheral blood leucocyte counts were not statistically significant （P ＞ 0.05）.CONCLUSIONS：Clinical pharmacist＇s intervention on the prophylactic use of antibiotics during perioperative period was proved to be feasible and effective and it played an active role in perioperative use of prophylactic antibiotics.
出处
《中国医院用药评价与分析》
2014年第4期331-334,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
青岛市年度医药科研指导计划项目(No.2011-WSZD064)
关键词
甲状腺手术
围术期
抗菌药物
切口感染率
Thyroid surgery
Perioperative period
Antibiotics
Wound infection rate
