中药植物雌激素双向调节的机制研究

Study on two-way adjustment mechanism of traditional Chinese medicine phytoestrogens

近年来由于合成类雌激素在治疗中副作用明显,中药植物雌激素在一些雌激素(过多或缺乏)相关疾病的治疗中带来了积极的效果.这类中药具有双向调节的"扶正"作用,故其作用机制研究也广泛的开展起来.主要包括与雌激素核受体的相互作用、对雌激素合成相关酶的调控、影响膜受体途径等.通过查阅相关文献,总结了植物雌激素双向作用机制及其研究的思路和方法,以期为临床上植物雌激素的应用以及其作为保健品的开发提供可靠的借鉴及依据.

Recently , the side-effects of the synthetic estrogenic hormone in treatment are found evidently .The application of traditional Chinese medicine phytoestrogen in the related diseases （ overabundance or deficiency ） treatment has acquired positive supports and results . This kind of traditional Chinese medicine has a two-direction “strengthening the body resist-ance” function ,thus there are more researches on its mechanism of action .The researches of this area mainly include the interaction of the estrogenic hormone and hormone receptor , the enzyme ’ s affect in the estrogenic hormone ’ s synthesis and the avenue to the membrane re-ceptor.This paper summarized the related researches in the area of the mechanism of phy-toestrogen’s two-direction effect.And expect to offer experiential and theoretical basis to the clinical application of the phytoestrogen and the exploit of health products .