摘要
目的检测EB病毒(EBV).潜伏膜蛋白1(LMPl)在作为癌前病变的慢性萎缩性胃炎(CAG)伴肠上皮化生胃黏膜中的表达,探讨其在胃癌发生、发展过程中的作用。方法应用免疫组织化学sP法检测经病理确诊的45例慢性浅表性胃炎(CSG)组织、63例CAG伴肠上皮化生组织、36例胃癌组织中EBV—LMP1的表达。结果45例CSG和36例胃癌组织中未见EBV-LMP1的表达,63例CAG伴肠上皮化生胃黏膜组织有23例阳性,阳性率为36.5%(23/63),主要定位于细胞核,明显高于CSG及胃癌中的表达,差异有统计学意义(尸值均为0.000)。结论CAG伴肠上皮化生组织中存在EBV-LMP1表达,明显高于CSG及胃癌组织,提示EBV感染可能在胃癌发生的早期阶段起重要作用。
Objective To investigate the expression of Epstein-Barr virus (EBV)- latent membrane protein 1 (LMP1) in chronic atrophic gastritis (CAG) with intestinal metaplasia and discuss its effect on gastric cancer. Methods Immunohistochemistry was used to examine the expression of EBV-LMP1 in 45 cases of chronic superficial gastritis (CSG), 63 cases of CAG with intestinal metaplasia and 36 eases of gastric cancer. Results There was no expression of EBV-LMP1 in CSG and gastric cancer, while the positive rate of EBV-LMP1 in CAG with intestinal metaplasia was 36.5%(23/63) and EBV-LMP1 was mainly stained in the cell nucleus. The expression of EBV-LMP1 in CAG with intestinal metaplasia was significantly higher than that in CSG and gastric cancer, and there was significant difference (P = 0.000). Conclusions EBV-LMP1 is expressed in CAG with intestinal metaplasia. The expression of EBV-LMP1 is significantly higher than that in CSG and gastric cancer indicating that EBV infection in gastric carcinogenesis may play an important role in the early stages.
出处
《中国医师进修杂志》
2014年第13期30-33,共4页
Chinese Journal of Postgraduates of Medicine
关键词
胃炎
萎缩性
EB病毒潜伏膜蛋白1
肠上皮化生
Gastritis, atrophic
Epstein-Ban" virus -latent membrane proteinl
Intestinalmetaplasia