血清游离氨基酸及VEGF与冠心病的相关性研究

Relation between serum free amino acid,VEGF and coronary heart disease

目的：分析血清游离氨基酸及血管内皮生长因子（VEGF）与冠心病的相关性。方法：选取2012年5月～2013年9月本院收治的58例冠心病患者为观察组，并以同期冠脉造影阴性的58例为对照组，比较两组血清游离氨基酸及VEGF水平，同时比较观察组不同Gensini积分水平者的检测结果，以Logistic分析血清检测指标及VEGF与疾病的关系。结果：观察组血清赖氨酸、苯丙氨酸、蛋氨酸、酪氨酸、丙氨酸及VEGF均高于对照组，而牛磺酸则低于对照组，且Gensini积分重度患者的上述检测指标水平波动大于轻、中度患者，中度患者大于轻度患者，差异均有统计学意义（P均〈0．05），经Logistic分析上述血清检测指标及VEGF与疾病有密切的关系。结论：血清游离氨基酸及VEGF与冠心痛关系密切，在疾病治疗过程中应注意对其进行有效的干预。

Objective： To investigate and analyze the relation between the serum free amino acid, VEGF and coronary heart disease. Methods：A total of 58 patients with coronary heart disease in our hospital from May 2012 to September 2013 were selected as observation group,58 cases with negative coronary angiography at the same time as the control group. Serum free amino acid, VEGF levels and Gensini integral of two groups were detected and compared, and the relation between the serum indexes and coronary heart disease were analyzed by Logistic analysis. Results： The serum lysine, phenylalanine, methionine, tyrosine, alanine and VEGF were all higher than those of control group, taurine was lower than that of control group. Detection levels fluctuation of patients with severe disease of Gensini integral werehigher than those of patients with mild and moderate disease, and the change of patients with moderate disease were higher than those of patients with mild disease （all P〈0.05）. Conclusion.The relation between the serum free amino acid,VEGF and vened during the treatment coronary heart disease is closely,and these indexes should be effectively inter of disease.