增液汤加减灌肠治疗美施康定引起便秘25例疗效观察

Clinical observation on 25 cases of constipation induced by morphine with retention enema of modified minor decoction of Zenye Decoction

目的观察增液汤加减灌肠治疗美施康定引起便秘的临床疗效。方法将50例美施康定引起的便秘患者随机分为2组,治疗组25例采用增液汤加减灌肠治疗,对照组25例采用1%~2%肥皂水灌肠治疗,对2组临床疗效、不良反应等情况进行比较。结果治疗组显效15例,有效8例,无效2例,总有效率为92%;对照组显效10例,有效7例,无效8例,总有效率为68%。2组总有效率比较差异有统计意义（P〈0.05）,表明治疗组临床疗效明显优于对照组。治疗组不良反应发生率为12%,对照组为36%,2组比较差异有统计意义（P〈0.05）。在灌肠液保留时间、灌肠治疗72 h内自主排便次数等方面比较,2组差异无统计意义（P〉0.05）。结论增液汤加减灌肠治疗美施康定引起的便秘疗效确切,可在临床中推广应用。

Objective To observe the clinical effect of retention enema of modified minor decoction of Zenye Decoction in treating constipation induced by morphine. Methods 50 cases were randomly divided into treatment group （25 cases） and control group （25 cases）. The treatment group was intervened by retention enema of modi- fied minor decoction of Zenye Decoction. The control group was treated with soapsuds enema （1% -2% ）. The adverse reaction and clinical effect, etc. were compared. Results The total effective rate of the treatment group was 92% , the control group was 68%. There was significant difference between two groups （P〈0.05）. The clini- cal effect of treatment group was superior to that of control group. The incidence of adverse reaction was 12% and 36% respectively. There was significant difference between two groups （P〈0.05）. The retention time and times of automatic defection in 72 h were also compared. There was no significance （P〉0.05）. Conclusion With reten- tion enema of modified minor decoction of Zenye Decoction, treatment of constipation induced by morphine has a determined curative effect. It can be popularized and applied.