心外膜脂肪厚度与非肥胖患者冠心病的相关研究

Correlation between epicardial adipose tissue thickness and coronary heart disease in nonobese patients

目的探讨超声测量的心外膜脂肪组织(epicardial adipose tissue,EAT)厚度与非肥胖患者冠心病(coronary heart disease,CAD)的相关性。方法选取2013年5-8月本院心内科住院,诊断为冠心病的非肥胖患者64例,男36例,女28例,收集患者临床资料,静脉取血行实验室检查,所有患者均行冠脉造影和超声心动图检查。31例因胸痛入院,冠脉造影检查结果正常的非肥胖患者作为对照组。结果非肥胖冠心病组EAT厚度显著高于对照组(8.1±1.7 mm vs 5.3±1.2 mm,P<0.01)。冠心病多支病变组EAT厚度显著高于单支病变组(8.8±1.6 mm vs 7.3±1.5 mm,P<0.05)。结论非肥胖冠心病患者EAT厚度显著增高,即使是体质量正常患者心外膜脂肪显著增厚也可能是冠心病的一个危险因素。

Objective To study the correlation between epicardial adipose tissue （EAT） thickness and coronary heart disease （CHD） in non-obese patients. Method s Clinical data about 64 non-obese CHD patients （36 males and 28 females） admitted to our hospital from May 2013 to August 2013 were collected. Venous blood samples were taken for laboratory testing. The patients underwent coronary arteriography and echocardiography. Thirty-one non-obese patients with normal coronary angiography served as controls. Results The EAT was significantly thicker in non-obese CAD patients than in controls and in non-obese CAD patients with multiple vessel lesions than in those with a single vessel lesion （8.1 ± 1.7 mm vs 5.3 ± 1.2 mm, P 〈 0.01; 8.8 ± 1.6 mm vs 7.3 ± 1.5 mm, P 〈 0.05）. Conclusion The EAT is significantly thicker in non-obese CHD patients. The epicardial fat may be a risk factor for CHD even in patients with a normal weight.