论多囊卵巢综合征患者高雄激素血症的发生机制

Pathogenetic mechanism of hyperandrogenism among sufferers with polycystic ovary syndrome

多囊卵巢综合征（ polycystic ovary syndrome ，PCOS ）是年轻妇女最常见的内分泌疾病，也是引起妇女体内雄激素过多的常见原因，发生率约占生育年龄妇女的5%～10%，其临床表现和生化特征多样化，主要是由于雄激素过多引起的一系列严重内分泌、代谢、生殖和心血管系统紊乱症状。众所周知，高雄激素血症是PCOS的主要生化特征，且PCOS患者雄激素的发生机制复杂，正确认识并防治高雄激素血症成为治疗PCOS的关键。下面就PCOS雄激素的形成机制有关研究进行综述。

Polycystic ovary syndrome（PCOS）is the mostcom monendocrine disease among young women,which is also a common cause of excessive androgens in women with the incidence rate ranging from 5% to 10% among the child bearing-age women .It has diversified clinical and biochemical characteristics,mainly including a series of serious disorders in internal secretion ,supersession ,reproduction ,and cardiovascular system due to excessive androgen .As is known to all,hyperandrogenism is the main biochemical characteristics of polycystic ovary syndrome,and the androgenic mechanism is complex for PCOS sufferers,so the correct understanding for the prevention and treatment of hyperandrogenism has become the key to the treatment of polycystic ovary syndrome.The paper summarizes the relevant research on the form ation mechanism of androgen in PCOS .