瑞舒伐他汀治疗原发性高血压的临床疗效及其对动脉粥样硬化的影响

Clinical Effect of Rui Shu Vatatin on Essential Hypertension and Carotid Atherosclerosis

目的观察瑞舒伐他汀治疗原发性高血压（EH）的临床疗效及其对动脉粥样硬化（As）的影响。方法选择2012年1月一2013年10月东营市第二人民医院住院或门诊治疗的EH患者128例，将其随机分为观察组79例和对照组49例。对照组采用常规治疗，观察组在常规治疗的基础上给予瑞舒伐他汀治疗，两组疗程均为6个月。治疗前后检测患者血脂水平及颈动脉内膜中层厚度（CAIMT），并观察两组临床疗效。结果治疗前，两组患者TC、TG、LDL—C、HDL—C水平及CAIMT比较，差异均无统计学意义（P〉0．05）；治疗6个月后，观察组TC、TG、LDL—C水平及CAIMT低于对照组，HDL—C水平高于对照组（P〈0．01）。观察组总有效率为93．7％（74／79），高于对照组的65．3％（32／49）（P〈0．05）。结论瑞舒伐他汀治疗EH疗效显著，且可以通过改善患者血脂水平控制AS的发生发展。

Objective To investigate the effect of Rui Shu Vatatin on essential hypertension （EH） and carotid atherosclerosis （AS）. Methods 128 patients with EH admitted to our hospital from January 2012 to October 2013 were randomly divided into observation group （79 eases） and control group （49 cases）. Control group was given conventional treatment, observation group was given Rui Shu Vatatin on basis of conventional treatment, both treated for 6 months. The level of blood lipid and CAIMI were detected between two groups before and after treatmnet, the clinical effect between two groups was observed. Resuits Before treatment, the TC, TG, LDL - C, HDL - C and CAIMT between two groups showed no statistically significant （ P 〉0. 05） ; 6 months after treatment, the TC, TG, LDL - C and CAIMT in observation group were lower than those of in control group, HDL - C was higher （P 〈0. 01 ） . The total efficiency of observation group was 93.7% （74/79）, was higher than that of control group of 65.3% （32/49） （P 〈0.05）. Conclusion Rui Shu Vatatin in treating EH has a obvious effect, which can improve the level of blood lipid to control the development of AS.