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右美托咪啶与异丙酚对老年心血管病患者腹部手术全麻恢复期质量的影响 被引量:5

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摘要 目的比较右美托咪啶与异丙酚对老年心血管病患者腹部手术全麻恢复期质量的影响。方法择期行腹部手术的老年心血管病患者93例,ASA分级Ⅰ~Ⅱ级,年龄≥65岁,采用随机数字表法分为三组(n=31):右美托咪啶组(A组)、异丙酚组(B组)和对照组(C组),分别于麻醉诱导前15min静脉输注右美托咪啶0.2μg/kg (15ml )、异丙酚1.5mg/kg (15ml )或0.9%氯化钠注射液15ml ,输注时间15min。三组均采用全身麻醉,记录自主呼吸恢复时间、苏醒时间、拔除气管导管时间及全麻恢复期不良反应,采用视觉模拟评分(VAS )评估拔管后各时间点镇痛效果,Ramsay镇静评分评估镇静等级。结果与C组比较,A组和B组镇痛有效率提高(χ2=3.54、4.17,均 P<0.05),躁动、呛咳、心血管事件等不良反应的发生率降低(χ2=2.76、2.38、3.81、4.02、3.55、4.48,P<0.05),拔管后5min、30min、60min VAS评分均降低( t=2.10、2.45、2.54、2.36、2.78、2.91,均 P<0.05);A组和B组拔管后5min、30min Ramsay镇静评分均明显高于C组( t=2.87、3.02、2.69、3.15,均 P<0.05);A组拔管后60min的VAS评分和Ramsay镇静评分均优于B组,差异有统计学意义( t=2.31、2.55,均 P<0.05)。结论全麻诱导前静脉输注右美托咪啶可改善老年腹部手术患者全麻恢复期的质量。
出处 《心脑血管病防治》 2014年第2期127-130,共4页 CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
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