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线粒体去乙酰化酶SIRT3与衰老疾病 被引量：1

Mitochondrial Deacetylase SIRT3 and the Aging-related Diseases
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摘要 线粒体去乙酰化酶SIRT3是酵母Sir2同源蛋白,通过对线粒体多种蛋白质赖氨酸的去乙酰化修饰,它可以调控多种代谢过程,如脂肪酸的β-氧化作用、TCA循环、氧化磷酸化等.SIRT3可参与氧化应激反应,降低细胞内ROS水平;也可以作为一种肿瘤抑制因子,促进细胞的凋亡.在某些乳腺癌细胞中,SIRT3表达下调.敲除SIRT3或者SIRT3表达降低,可影响与代谢相关的衰老性疾病如心脏疾病、癌症等的发生.论文总结了近年去乙酰化酶SIRT3在代谢调控及癌症细胞凋亡中的分子机制以及SIRT3与心脏疾病、癌症的相互关系,希望为衰老疾病的预防和治疗提供一定的理论基础. Mitochondrial deacetylase SIRT3 is the homolog of yeast Sir2 and it can modulate diverse mitochondria-localized processes such as fatty acid β-oxidation, tricarboxylic acid （TCA） cycle and oxidative phosphorylation by deacetylation of the targeted lysine on the mitochondrial proteins. Furthermore, SIRT3 is involved in oxidative stress and reduces the cellular ROS level. SIRT3 also acts as a tumor suppressor to induce cancer cell apoptosis. In some breast carcinoma, the expression level of SIRT3 is down-regulated. Deletion or downregulation of SIRT3 in animal model promotes the onset of metabolic aging-related diseases, such as heart failure and cancer. In this review, we summarized the current evidences of deacetylase SIRT3 and the involved regulatory mechanism in metabolism and cancer cell apoptosis, and the correlation between heart failure, cancer with deacetylase SIRT3. It aims to provide some novel insights for prevention and treatment of the aging-related diseases.
作者 王琪琳
机构地区 聊城大学生命科学学院
出处 《聊城大学学报（自然科学版）》 2014年第1期61-68,共8页 Journal of Liaocheng University:Natural Science Edition
基金 国家自然科学基金(20971063)资助项目 博士科研启动基金
关键词 去乙酰化酶 SIRT3 线粒体 中间代谢 心脏疾病 癌症 衰老疾病 deacetylase, SIRT3, mitochondria, intermediary metabolism, heart failure, cancer, aging disease
分类号 Q279 [生物学—细胞生物学] Q255 [生物学—细胞生物学]
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参考文献52

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同被引文献15

  • 1赵晓琴.胆红素抗氧化作用及其与冠心病关系的研究进展[J].实用心脑肺血管病杂志,2015,23(1):141-143.
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  • 5FURUKAWA MANABU,XIONG YUE.BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase[J].Molecular and Cellular Biology,2005,25(1):162-171.
  • 6ZHU HHONG,ZHANG LI,AMIN A R,et al.Coordinated upregulation of a series of endogenous antioxidants and phase 2 enzymes as a novel strategy for protecting renal tubular cells from oxidative and electrophilic stress[J].Experimental Biology and Medicine,2008,233(6):753-765.
  • 7ZHAO ZHIQING.Oxidative stress-elicited myocardial apoptosis during reperfusion[J].Current Opinion in Pharmacology,2004,4(2):159-165.
  • 8CHEN YAOHUI,ZHANG JINYE,LIN YAN,et al.Tumour suppressor SIRT3 deacetylates and activates Manganese superoxide dismutase to scavenge ROS[J].EMBO Reports,2011,12(6):534-541.
  • 9HAFNER A V,DAI JING,GOMES A P,et al.Regulation of the m PTP by SIRT3-mediated deacetylation of Cyp D at lysine 166 suppresses age-related cardiac hypertrophy[J].Aging,2010,2(12):914-923.
  • 10蔡维霞,张军,胡大海.氧化和化学应激的防御性转导通路——Nrf2/ARE[J].中国生物化学与分子生物学报,2009,25(4):297-303. 被引量：36

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聊城大学学报（自然科学版）
2014年 第1期

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