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IDO在炎症性肠病中的研究进展 被引量：4

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摘要 炎症性肠病(IBD)是一组病因未明的慢性非特异性肠道炎性疾病,有学者认为其发病与肠道免疫耐受被打破有关。吲哚胺2,3-双加氧酶(indoleamine2,3-dioxygenase,IDO)是一种色氨酸代谢酶,能够抑制T细胞克隆增殖,诱导免疫耐受,在炎性反应发生时,其表达和活性增加。故IDO与IBD的发病机制关系密切,有可能在IBD的诊断、治疗方面发挥着重要的作用。
作者 卞秀梅 吴正祥
机构地区 安徽医科大学附属省立医院消化内科
出处 《国际消化病杂志》 CAS 2014年第2期106-109,共4页 International Journal of Digestive Diseases
关键词 炎症性肠病 吲哚胺2 3-氧化酶 色氨酸 犬尿氨酸
分类号 R574.62 [医药卫生—消化系统]
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参考文献24

  • 1Xavier R J,Podolsky DK.Unravelling the pathogenesis of inflammatory bowel disease.Nature,2007,448:427-434.
  • 2Abraham C,Cho JH.Inflammatory bowel disease.N Engl J Med,2009,361:2066-2078.
  • 3Mellor AL,Munn DH.IDO expression by dendritic cells:tolerance and tryptophan catabolism.Nat Rev Immunol,2004,4:762-774.
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  • 6Wolf AM,Wolf D,Rumpold H,et al.Overexpression of indoleamine 2,3-dioxygenase in human inflammatory bowel disease.Clin Immunol,2004,113:47-55.
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  • 8Jasperson LK,Bucher C,Panoskaltsis-Mortari A,et al.Inducing the tryptophan catabolic pathway,indoleamine 2,3 dioxygenase (IDO),for suppression of graft-versus-host-disease (GVHD) lethality.Blood,2009,114:5062-5070.
  • 9Ciorba MA,Bettonville EE,McDonald KG,et al.Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis.J Immunol,2010,184:3907-3916.
  • 10Harrington L,Srikanth CV,Antony R,et al.Deficiency of indoleamine2,3 dioxygenase enhances commensal-induced antibody responses and protects against Citrobacter rodentium induced colitis.Infect Immun,2008,76:3045-3053.

二级参考文献20

  • 1Huang L,Baban B,Johnson BA 3rd. Dendritic cells,indoleamine 2,3 dioxygenase and acquired immune privilege[J].International Reviews of Immunology,2010,(02):133-155.
  • 2Li Y,Tredget EE,Ghaffari A. Local expression of indoleamine 2,3-dioxygenase protects engraftment of xenogeneic skin substitute[J].Journal of Investigative Dermatology,2006,(01):128-136.
  • 3Fallarino F,Grohmann U. Using an ancient tool for igniting and propagating immune tolerance:IDO as an inducer and amplifier of regulatory T cell functions[J].Current Medicinal Chemistry,2011,(15):2215-2221.
  • 4Liu H,Liu L,Liu K. Reduced cytotoxic function of effector CD8+ T cells is responsible for indoleamine 2,3-dioxygenase-dependent immune suppression[J].Journal of Immunology,2009,(02):1022-1031.
  • 5S(o)rensen RB,Hadrup SR,Svane IM. Indoleamine 2,3-dioxygenase specific,cytotoxic T cells as immune regulators[J].Blood,2011,(07):2200-2210.
  • 6Liu H,Liu L,Fletcher BS. Novel action of indoleamine 2,3-dioxygenase attenuating acute lung allograft injury[J].American Journal of Respiratory and Critical Care Medicine,2006,(05):566-572.
  • 7Godin-Ethier J,Hanafi LA,Duvignaud JB. IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive[J].Molecular Immunology,2011,(1-2):253-259.
  • 8Zhao XS,Liu KY,Liu DH. Potential immunosuppressive function of plasma indoleamine 2,3-dioxygenase in patients with aGVHD after allo-HSCT[J].Clinical Transplantation,2011,(03):E304-E311.
  • 9No authors listed. Banff schema for grading liver allograft rejection:an international consensus document[J].Hepatology,1997,(03):658-663.
  • 10Akoglu B,Kriener S,Martens S. Interleukin-2 in CD8+ T cells correlates with Banff score during organ rejection in liver transplant recipients[J].Clinical and Experimental Medicine,2009,(04):259-262.

共引文献1

同被引文献36

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二级引证文献38

国际消化病杂志
2014年 第2期

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