中医综合治疗小儿热性惊厥临床研究

Clinical study of integrated traditional Chinese medicine in the treatment of children with febrile seizures

目的观察中医多种急救手段综合治疗小儿热性惊厥的有效性和安全性。方法本研究遵循随机对照原则．选择2012年10月～2013年12月东莞市中医院收治的热性惊厥患儿60例，分为治疗组、对照1组和对照2组．每组各20例。治疗组采用辨证针刺穴位联合醒脑静静滴，大承气汤免煎颗粒保留灌肠；对照1组采用辨证针刺穴位联合大承气汤免煎颗粒保留灌肠：对照2组采用苯巴比妥注射液（鲁米那）肌注联合补液及对乙酰氨基酚栓（小儿退热栓）纳肛。结果三组止惊时间治疗组为（1．45±0．34）min，对照1组为（1．56±0．63）min，对照2组为（3．98±1．74）min，治疗组与对照1组相当（P〉0．05）；治疗组比对照2组止惊快（P〈0．05）；三组退热时间，治疗组为（2．98±1．16）h，对照1组为（5．63±1．97）h，对照2组为（4．05±0．83）h，治疗组明显优于对照1组及对照2组，差异均有统计学意义（P〈0．05）。三组24h内惊厥复发率分别为5％、10％、20％，对照2组复发率最高。结论中医多种急救手段综合治疗小儿热性惊厥，可明显缩短止惊及退热时间，减少24h内惊厥复发率，值得临床推广。

Objective To observe the safety and effectiveness of various first-aid methods of traditional Chinese medicine in the treatment of febrile seizures. Methods This study obeyed the principle of randomized controlled. 60 cases of febrile seizures admitted to Dongguan Hospital of Traditional Chinese Medicine from October 2012 to Decem- ber 2013 were chosen and divided into treatment group, control group 1 and control group 2, 20 patients in each group. Treatment group was given acupuncture combined with Xingnaojing Injection, Dachengqi Decoction granules enema. The control group 1 was given acupuncture combined with Dachengqi Decoction granules enema; the control group 2 was given phenobarbital injection （Lu Mina） Injection combined with fluid infusion and Paracetamol Suppositories （Xi- aoer Tuire suppositories） anus. Results Compared with three groups of anti convulsion time, the treatment group was （1.45±0.34） min, the controlgroup 1 was （1.56±0.63） min, the control group 2 was （3.98±1.74） min. The treatment group and the control group 1 was simple （P 〉 0.05）, the treatment group was faster than the control group 2 （P 〈 0.05）. Comparison of the cooling time, the treatment group was （2.98±1.16） h, the control group 1 was （5.63±1.97） h, the control group 2 was （4.05±0.83） h. The treatment group was significantly better than the control group 1 and control group 2, respectively, compared with two groups, there were significant differences （P 〈 0.05）. Comparison of 24 hours of seizure recurrence rate, three groups were 5%, 10%, 20%, the control group 2 had the highest recurrence rate. Conclusion The various first-aid methods of traditional Chinese medicine in the treatment of febrile seizures can short- en the anticonvulsion and cooling time, reduce seizure recurrence rate within 24 hours, which is worthy of clinical pro- motion.