双心医学在急性冠脉综合征患者诊疗中的应用

Application of double heart medicine in the treatment and diagnosis of acute coronary syndrome

目的 分析双心医学在急性冠脉综合征患者诊疗中的应用与临床意义。方法 选择2013年1月～2014年1月广东省东莞市石碣医院收治的64例急性冠脉综合征患者为研究对象，将其随机分为对照组和观察组．每组各32例。对照组采用常规治疗，观察组在对照组的基础上采用双心医学诊疗。比较两组患者的治疗效果和治疗前后心理状态、血脂、心功能情况及心率失常发生率的变化。结果 观察组患眷治疗总有效率为90．63％，明显高于对照组（68．75％），差异有高度统计学意义（P〈0．01）；治疗后，两组患者抑郁焦虑评分低于治疗前（P〈0．05），且观察组[（0．91±0．13）分]低于对照组[（1．53±0．27）分]（P〈0．01），观察组患者抑郁焦虑情况改善程度明显优于对照组；治疗后，观察组总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平[（4．01±0．79）、（0．83±0．17）、（2．28±0．47）mmol／L]均优于对照组[（4．47±0．64）、（1．03±0．25）、（2．67±0．41）mmol／L]（P〈0．01），且均低于治疗前（均P〈0．05）。两组脑钠肽前体、左室射血分数及心率失常发生率均较治疗前有所改善（P〈0．05），且观察组各指标明显优于对照组（P〈0．05或P〈0．01）。结论 双心医学在急性冠脉综合征患者的诊疗中，效果显著，具有一定的临床意义。

Objective To analyze the application and clinical significance of double heart medical in diagnosis and treatment of the acute coronary syndrome. Methods 64 patients with acute coronary syndrome from January 2013 to January 2014 in Shijie Hospital of Dongguan City were selected as study objects, and they were randomly divided into observation group and control group, with 32 cases in each group. The control group were given conventional treatment, observation group were given double heart medicine in addition. The therapeutic effect, change of mental status, blood lipids, cardiac function and incidence of arrhythmia in two groups before and after treatment were compared. Results The total effective rate of the observation group was 90.63%, obviously better than that of the control group （68.75%）, the difference was statistically significant （P 〈 0.01）. The depression and anxiety scores of two groups after treatment were lower than those before treatment （P 〈 0.05）, and the scores of observation group [（0.91±0.13） scores[ was lower than that of control group [（1.53±0.27） scores[ （P 〈 0.01）, the improvement degree of anxiety and depression in observation group was better than that of control group. The level of total cholesterol, high density lipoprotein-cholesterd, low density lipoprotein-cholesterd of observation group [（4.01±0.79）, （0.83±0.17）, （2.28±0.47） mmol/L] were better than those of control group [（4.47±0.64）, （1.03±0.25）, （2.67±0.41） mmol/L] （P 〈 0.01）, and those in two groups after treatment were lower than before treatment （all P 〈 0.05）. After treatment, the NT-proBNP, left ventricular ejection fraction, and the incidence of arrhythmia of two groups were improved compared with those before treatment （P 〈 0.05）, and these index degree of observation group were better than those of control group （P 〈 0.05 or P 〈 0.01）. Conclusion The effect of double heart medicine in the treatment of patients with acute coronary syndrome is significant, has certain clinical significance.