长期服用赖诺普利、苯磺酸氨氯地平及厄贝沙坦对高血压病患者心肺功能的影响比较

Comparison of long term effects of lisinopril,amlodipine besylate and ibesartan on cardio-pulmonary function in hypertensive patients

目的比较长期服用血管紧张素转化酶抑制剂赖诺普利、钙离子拮抗剂苯磺酸氨氯地平及血管紧张素Ⅱ受体拮抗剂厄贝沙坦对高血压病患者的心肺功能的影响。方法选择2级高血压病患者96例,随机分为3组,分别服用赖诺普利片10 mg·d-1,苯磺酸氨氯地平片5 mg·d-1,厄贝沙坦片150 mg·d-1。比较3组病人服药6及12个月后的血压控制情况、运动时最大摄氧量。结果服药6及12个月后,赖诺普利组血压下降程度分别为:(33.09±15.50)/(14.18±9.44)mmHg、(36.49±17.10)/(15.28±8.24)mmHg;苯磺酸氨氯地平组血压下降程度分别为:(31.80±12.93)/(12.72±9.76)mmHg、(33.85±15.82)/(17.28±7.56)mmHg;厄贝沙坦组血压下降程度分别为:(32.90±14.82)/(15.21±10.85)mmHg、(33.85±13.72)/(17.42±11.54)mmHg。3组差别无统计学意义。服药6及12个月后运动时公斤体重最大摄氧量结果(x±s)分别为,赖诺普利组:20.22±1.15、20.99±1.37;苯磺酸氨氯地平组:17.87±1.43、18.00±1.13;厄贝沙坦组:17.98±1.33、18.26±1.53。3组进行比较,赖诺普利组病人长期服药后运动时最大摄氧量改善。结论长期服用赖诺普利可以控制血压并改善高血压病患者的心肺功能。

Objective To compare the effects of long - term use of angiotensin converting enzyme inhibitor lisinopril, calcium antagonist amlodipine besylate and angiotensin Ⅱ receptor antagonist irbesartan on cardio - pulmonary function in Hypertensive patients. Methods 96 patients with hypertension were randomly divided into three groups,treated with lisino-pril tablets 10 mg·d - 1 ,amlodipine besylate tablets 5 mg·d - 1 and irbesartan tablets 150 mg·d - 1 ,respectively. After 6 and 12 months,compared three groups of patients with blood pressure and VO2max . Results After 6 and 12 months,the de-creases in blood pressure levels of lisinopril group were：（33. 09 ± 15. 50）/（14. 18 ± 9. 44）mmHg,（36. 49 ± 17. 10）/（15. 28 ± 8. 24）mmHg,amlodipine besylate group were：（31. 80 ± 12. 93）/（12. 72 ± 9. 76）mmHg,（33. 85 ± 15. 82）/（17. 28 ± 7. 56）mmHg and irbesartan group were（32. 90 ± 14. 82）/（15. 21 ± 10. 85）mmHg,（33. 85 ± 13. 72）/（17. 42 ± 11. 54）mmHg. There were no significant difference. 6 and 12 months later,VO2max of patients respectively,lisinopril group：20. 22 ± 1. 15,20. 99 ± 1. 37;amlodipine besylate group：17. 87 ± 1. 43,18. 00 ± 1. 13;irbesartan group：17. 98 ± 1. 33, 18. 26 ± 1. 53. Compared with the other groups,VO2max of patients in lisinopril group were improved. Conclusion Long term use of lisinopril can control blood pressure and improve cardio - pulmonary function of hypertensive patients.