炎症性肠病患者的自主神经功能改变

Changes of autonomic nervous function in patients with IBD

目的探讨炎症性肠病(IBD)患者的自主神经功能改变状况。方法分析2012年1月至2014年2月在消化内科接受住院或是门诊治疗的IBD患者[溃疡性结肠炎(UC)和克罗恩病(CD)]的临床资料,并选取正常体检者作为对照组。两组受试者均行迷走副交感神经和交感肾上腺能神经功能的检查。结果共纳入研究对象105例,其中IBD患者70例(UC患者38例,CD 32例),对照组35例。IBD患者的卧立位心率变化值均显著低于对照组,差异具有统计学意义(t=4.025,P<0.001);两组受试者的瓦氏指数相比差异无统计学差异(t=0.400,P=0.690)。IBD组患者的卧立位血压差值显著高于对照组(t=2.845,P<0.001);IBD组患者的握力实验血压差值均显著低于对照组,差异具有统计学意义(t=8.273,P<0.001)。结论 IBD患者相对于正常对照组,其交感肾上腺素能神经系统功能明显增强,而迷走副交感神经功能相对有所减弱。

Objective To investigate the changes of autonomic nervous function in patients with inflammation bowel diseases（IBD）. Methods From 2012 January to 2014 February,clinical data was analyzed for inpatient or outpatient treatment of IBD patients（UC and CD）in our hospital department of internal medicine digestion. Health examinations people were selected as the normal controls. Two groups of subjects un-derwent vagal parasympathetic and sympathetic adrenergic nerve function tests. Results 70 cases of IBD patients were selected into this study. The control group included 35 cases. IBD group with orthostatic heart rate values were significantly lower than those in the control group（ t = 4. 025,P〈 0. 01）. Warburg index of two groups showed no significant difference（ t = 0. 400,P = 0. 690）. IBD patients with orthostatic blood pressure values were higher than in the control group（ t = 2. 845,P〈 0. 001）. While difference grip experimental blood pressure in IBD patients were significantly lower than the control group（ t = 8. 273,P〈 0. 001）. Conclusion In patients with IBD compared with normal control group, the sympathetic adrenergic nerve system function was strengthened,and the vagal parasympathetic nerve function relatively weakened.