血清降钙素原和C反应蛋白水平改变在支原体肺炎患儿中的临床意义

Changes of serum procalcitonin and C-reactive protein levels in children with mycoplasma pneumonia

目的探讨血清降钙素原和C反应蛋白水平改变在支原体肺炎患儿中的临床意义。方法选择支原体肺炎、细菌性肺炎患儿各67例为支原体肺炎组和细菌性肺炎组,选择健康体检儿童67例为健康对照组。检测各组血清降钙素原(PCT)和C反应蛋白(CRP)水平并分析。结果支原体肺炎组急性期血清PCT水平显著高于健康对照组,但显著低于细菌性肺炎组(P均<0.05)。支原体肺炎组、细菌性肺炎组血清CRP水平显著高于健康对照组(P<0.05),但两者CRP水平比较无显著差异。治疗后发现恢复期支原体肺炎组血清PCT、CRP水平显著下降,与健康对照组无统计学差异(P均>0.05)。结论早期联合检测呼吸道感染患儿PCT与CRP水平可帮助早期鉴别支原体感染肺炎和细菌性感染肺炎,并可作为疗效观察的参考依据。

Objective To investigate the changes of serum procalcitonin（PCT）and C - reactive protein（CRP）levels in children with mycoplasma pneumonia. Methods Serum PCT and CRP levels in each group of children with mycoplasma pneumonia（n = 67）or bacterial pneu-monia（n = 67）,and healthy children（n = 67）were detected and analyzed. Results In acute phase,serum PCT level was significantly higher in mycoplasma pneumonia group than healthy control group,but significantly lower than bacterial pneumonia group（all P 〈 0. 05）. Serum CRP level in mycoplasma pneumonia group and bacterial pneumonia group was significantly higher than healthy control group（ P 〈 0. 05）,but no sig-nificant difference between mycoplasma pneumonia group and bacterial pneumonia group. After treatment,serum PCT and CRP levels were signifi-cantly decreased in children with mycoplasma pneumonia,but not significantly different from those of control group（all P ﹥ 0. 05）. Conclusion Combined early detection of serum PCT and CRP for children with respiratory infection may help early identification of mycoplasma pneumonia and bacterial pneumonia,and provide reference for the treatment effect.