体重指数对上游治疗的阵发性心房纤颤老年患者复发影响的研究

Study on impact of different body mass indexes on recurrence of paroxysmal atrial fibrillation in elder patients

目的研究不同体重指数与上游治疗的阵发性心房纤颤(房颤)老年患者复发的关系。方法选择2011年1月至2013年12月收治的经口服上游抗心律失常药物治疗满12个月的阵发性心房纤颤的老年患者,根据体重指数将患者分为体重正常组(n=28)、超重组(n=18)和肥胖组(n=15)。比较三组患者的一般资料、其他合并症以及随访12个月内的房颤的复发率。结果随访期间肥胖组患者房颤的发生次数明显高于其余两组,差异有统计学意义(P<0.05);随访12个月超重组和肥胖组的房颤复发率明显高于体重正常组,差异有统计学意义(P<0.05)。超重组和肥胖组患者的左心房内径、左心室舒张末期内径以及合并高血压、糖尿病和阻塞性睡眠呼吸暂停综合征的比率明显高于体重正常组,脑钠肽水平明显低于体重正常组,差异有统计学意义(P<0.05)。结论体重指数与上游治疗的老年阵发性房颤患者房颤复发的发生率相关,肥胖和超重患者的发生率高于体重正常患者。

Objective To study the relationship between different body mass indexes（ BMI）and recurrence of paroxysmal atrial fibrilla-tion（ AF）in elder patients. Methods The elder patients with AF receiving upstream antiarrhythmic drugs for 12 months in this hospital during January 2011 to December 2013 were divided into normal weight group（ n=28 ）,overweight group（ n=18 ）and obesity group（ n=15 ）. The general information,other complications and recurrence of AF within 12 months during the follow-up period were compared among these three groups. Results The incidence of AF in obesity group was significantly higher than that of other two groups（ P 〈0. 05）. The recurrence rate of AF in obesity group and overweight group was significantly higher than that of normal weight group after follow-up for 12 months（ P 〈0. 05）. The diameter of left atrium,diastolic diameter of left ventricle,and the incidence of hypertension,diabetes and obstructive sleep apnea in obesity group and overweight group were significantly higher than those of normal weight group（ P 〈0. 05）,while the level of B-type natriuretic peptide （BNP）was significantly lower than that of normal weight group（ P 〈0. 05）. Conclusion BMI is closely related to the recurrence of paroxysmal AF in elder patients,and the incidence is higher in patients with overweight and obesity than that of patients with normal weight.