卡泊三醇联合卤米松序贯治疗斑块状银屑病疗效分析

The treatment of clcipotriol cream conbined with halometasone cream in plaque psoriasis

目的探讨卡泊三醇联合卤米松序贯治疗寻常型斑块状银屑病的疗效及安全性。方法选取96例寻常型斑块状银屑病患者,随机分为两组。治疗组联合使用卡泊三醇软膏和卤米松软膏,分三阶段进行序贯治疗;对照组单纯外用卡泊三醇软膏早、晚各1次。治疗后第2、4、6周对两组患者进行疗效判断和比较,并观察治疗过程出现的不良反应。结果联合治疗组在治疗后在第2、4、6周复诊时总有效率分别为54.17%、68.89%和84.44%;对照组在治疗后在第2、4、6周复诊时总有效率分别为33.33%、46.67%和63.41%。与对照组相比,治疗组在各个观察时间点疗效均优于对照组,差异均有统计学意义(P<0.05)。不良反应主要表现为出现局部红斑、灼热、瘙痒和色素沉着,治疗结束后症状均能缓解。结论卡泊三醇联合卤米松序贯性治疗斑块状银屑病,效果显著,不良反应较轻,是较好的治疗方案。

Objective To investigate the clinical efficacy and safety of calcipotriol cream combined with halometasone cream in the treat-ment of plaque psoriasis. Methods In this trail ,we randomly assigned 96 patients who had a plaque psoriasis to undergo a sequential therapy of calcipotriol cream combined with halometasone cream or calcipotriol cream only（ control group）. The whole patients were treated for 6 weeks. The patients were evaluated for efficacy on week 2,4 and 6 after the initial treatment. Adverse effects were also recorded at each vist. Results The total effective rate was 54. 17% after a sequential therapy for 2 weeks ,68. 89% for 4 weeks and 84. 44% for 6 weeks. In the control group,total effective rate at each time point was 33. 33%,46. 67% and 63. 41%. A significant difference was noticed between two groups（ P 〈0. 05）. A temporary local erythema,burning,itching and pigmentation may occurred during treatment,and all symptoms can relieve after the treatment. There was one serious adverse event in each group. Compared with control group,the sequential treatment group had lower incidence of adverse re-action（ P 〈0. 05）. Conclusion Curative effects of patients treated with a sequential therapy of calcipotriol cream combined with halometasone cream were better than the treatment of calcipotriol cream alone.