紫杉醇联合顺铂腹腔热灌注化疗治疗晚期卵巢癌的疗效观察

The clinical observation of paclitaxel combined with cisplatin intraperitoneal chemotherapy in the treatment of advanced ovarian cancer

目的观察紫杉醇联合顺铂腹腔热灌注化疗治疗晚期卵巢癌的临床疗效。方法 78例晚期卵巢癌患者随机分为两组,观察组(n=40例)采用紫杉醇联合顺铂腹腔热灌注化疗治疗,对照组(n=38例)采用紫杉醇联合顺铂静脉注射化疗治疗。比较两组临床疗效、无进展生存期、中位生存期、1年生存率、2年生存率、3年生存率及不良反应等。结果观察组腹腔热灌注化疗有效率(80.0%)明显高于对照组静脉滴注化疗有效率(63.2%)(P<0.05);观察组无进展生存期、中位生存期、1年生存率、2年生存率和3年生存率均明显高于对照组(P<0.05);观察组毒副反应发生率(42.5%)明显低于对照组(60.5%)。结论紫杉醇联合顺铂腹腔热灌注化疗治疗晚期卵巢癌疗效显著,可明显提高患者生存期及生存率,不良反应较少,值得临床推广应用。

Objective To observe the clinical curative effect of paclitaxel combined with cisplatin intraperitoneal chemotherapy in the treatment of advanced ovarian cancer. Methods 78 patients with advanced ovarian cancer were randomly divided into 2 groups,the observation group and the control group. The observation group（ n=40 cases）was treated with paclitaxel combined with cisplatin intraperitoneal chemotherapy treatment. The control group（ n=38 cases）was treated with paclitaxel combined with cisplatin chemotherapy by intravenous injection. The clini-cal efficacy,progression free survival,median survival time,survival rate of 1 years,2 years survival rate,3 year survival rate and adverse reaction of two groups were observed and compared. Results The efficiency of observation group（ intraperitoneal hyperthermic perfusion chemotherapy） （80%）was significantly higher than that of control group（intravenous chemotherapy）（63. 2%）（ P 〈0. 05）. The progression free survival, median survival time,survival rate of 1 years,2 years survival rate and 3 year survival rate of observation group were significantly higher than those of the control group（ P 〈0. 05）. The incidence rate of side reaction in observation group（42. 5%）was significantly lower than that of the con-trol group（60. 5%）. Conclusion The treatment of paclitaxel combined with cisplatin intraperitoneal hyperthermic perfusion chemotherapy for advanced ovarian cancer had a significantly curative effect. This method could significantly improve the survival duration and survival rate,less ad-verse reactions. It was worthy of clinical application.