摘要
MCF-7细胞是caspase 3功能缺失的乳腺癌细胞,本研究结果发现土槿皮乙酸(PAB)可激活caspase 3的上游蛋白caspase 8和caspase 9来诱导细胞凋亡,同时PAB通过P53蛋白诱导人乳腺癌细胞MCF-7凋亡。本试验结果为进一步阐明PAB抗乳腺癌奠定了基础。
The assay was aimed to study the inhibitory mechanism of pseudolaric acid B （PAB） in MCF-7 cell line. MCF-7 cell was human breast cancer cell lacking of caspase 3 function. In this study, it was found that PAB activated caspase 8 and caspase 9 to induce cell apoptosis. Meanwhile PAB up-regulated P53 protein expression. Therefore PAB induced MCF-7 cell apoptosis through increasing P53 protein expression and promoting the activation of caspase 8 and caspase 9.
出处
《中国畜牧兽医》
CAS
北大核心
2014年第5期155-158,共4页
China Animal Husbandry & Veterinary Medicine
基金
吉林省中医药管理局(2012-030)
