止咳平喘颗粒的祛痰、镇咳及平喘作用研究

Study on the Effects of Zhike Pingchuan Granules on Expectorant,Antitussive and Antiasthmatic

试验旨在通过动物试验观察止咳平喘颗粒的祛痰、镇咳及平喘药理作用。采用毛细玻管法观察其祛痰作用;采用浓氨水引咳法观察其止咳作用;采用喷雾致喘法观察其平喘作用。结果显示,止咳平喘颗粒低剂量组增加的痰液分泌量与空白对照组相比差异显著(P<0.05),中、高剂量组增加的痰液分泌量与空白对照组相比均差异极显著(P<0.01);止咳平喘颗粒高、中、低剂量组对于延长咳嗽潜伏期和减少咳嗽次数与空白对照组相比均差异极显著(P<0.01);止咳平喘颗粒低剂量组延长4%氯化乙酰胆碱引喘豚鼠的潜伏期与空白对照组相比差异不显著(P>0.05),高、中剂量组延长4%氯化乙酰胆碱引喘豚鼠的潜伏期与空白对照组相比均差异极显著(P<0.01)。结果表明止咳平喘颗粒具有祛痰、镇咳及平喘作用。

The assay was aimed to investigate the effects of Zhike Pingchuan granules on expectorant, antitussive and anti- asthmatic by animals experiment. Capillary method was used to observe the expectorant effect in rat, the cough model induced by strong ammonia in mice was used to observe the antitussive effect,asthma model induced by spraying method was used to ob- serve the antiasthmatic effect. The results showed that the low dosage group of Zhike Pingehuan granules significantly increased excretion of trachea quantity compared with the blank control group （P〈0.05）, and there were extremely significant differ- ences between the blank control group and middle,high dosage groups （P〈0.01）;the three high,middle and low dosage groups of Zhike Pingchuan granules extremely significantly prolonged the latent period of cough and decreased the frequency of cough induced by strong ammonia compared with the blank control group （P〈0.01）; the low dosage group of Zhike Pingchuan gran- ules had not significantly prolonged the latent period of asthma induced by 4 % acetylcholine chloride compared with the blank control group （P〉0.05）, and middle and high dosage groups had extremely significant difference compared with the blank con- trol group （P〈0.01）. Zhike Pingehuan granules had the effects of expectorant,antitussive and antiasthmatic.