Notch-1在木村病中的表达及意义

Expression of Notch-1 in Kimura's disease and its significance

目的：探讨Notch-1在木村病的表达，指导木村病患者的优化治疗。方法通过免疫组化SP方法评估Notch-1蛋白在40例木村病患者组织和15例慢性淋巴结炎组织中的表达，分析Notch-1与木村病临床病理资料及预后的关系。结果40例木村病患者中，男性患者占92.5%（37/40），7.5%（3/40）为女性患者，发病平均年龄为38岁。肿块的直径范围为1.0～6.5 cm。Notch-1在复发的11例木村病患者中，63.6%（7/11）高度表达，36.4%（4/11）低度或中度表达。Notch-1表达、嗜酸粒细胞计数、肿块最大直径与复发有统计学差异（P＜0.05），年龄、性别、肿块部位、肿块个数与复发无相关性（P＞0.05）。结论 Notch-1高表达可能为木村病复发患者的一个有效观察指标，可为预后提供评估途径及指导患者个体优化治疗。

Objective To investigate the expression of Notch-1 in Kimura＆#39;s disease （KD） and provide an optimal treatment for KD patients. Methods Immunohistochemical staining was performed in 40 cases of KD and 15 cases of chronic lymphnoditis. Expression of Notch-1 in different tissues and the correlation between the clinicopathological factors and prognosis of KD were analysed. Results Among the 40 KD patients, males （37/40） made up 92.5%and 7.5%for females （3/40） with an average age of 38 years. The range of mass size was 1.0-6.5 cm. For the 11 cases of recurrent KD, 63.6%（7/11） were highly expressed of Notch-1, 36.4% （4/11） were low or mediate expression of Notch-1. There was statistical significant between Notch-1 expression, peripheral eosinophilia（%）, the largest size of masses and recurrence of KD（P〈0.05）. Statistical significance were not found in the age, gender, the numbers of mass and mass location（P〉0.05）. Conclusion The highly expression of Notch-1 may be an effective observable indicator for KD relapsed patients and could guild for better personalized therapies for patients.