摘要
2型糖尿病患者动脉粥样硬化的发病率明显增高。糖尿病通过增加常规的危险因素(如血脂异常、高血压)或糖尿病特有的危险因子(如晚期糖基化终产物AGEs),促进动脉粥样硬化的发展。AGEs作为蛋白质或脂质与还原糖糖基化的终产物,在血管细胞中通过与RAGE结合促进炎症因子的表达,参与动脉粥样硬化的发展。近年来,关于AGEs及其受体(RAGE)对糖尿病动脉粥样硬化影响的研究较为深入。本文旨在对近年来有关AGEs/RAGE在糖尿病加速的动脉粥样硬化中作用的研究进展作一综述。
There is an increased morbidity of atherosclerosis in patients with type 2 diabetes. Diabetes may be associated with accelerated atherosclerosis by either increasing the conventional risk factors, such as dyslipidemia and high blood pressure, or diabetic-specific risk factor, such as advanced glycation end products (AGEs). AGEs are proteins or lipids that become glycated after exposure to sugars. By engaging in the RAGE, AGEs induce the expression of proinflammatory mediators in various vascular cell types. In recent years, further studies have shown the association between AGEs and RAGE in diabetes accelerated atherosclerosis. The following review will discuss the potential role of the advanced AGEs-RAGE axis in diabetes-accelerated atherosclerosis as a mediator in lesion development in patients with type 2 diabetes.
出处
《中华临床医师杂志(电子版)》
CAS
2014年第5期81-84,共4页
Chinese Journal of Clinicians(Electronic Edition)
基金
国家自然科学基金(81270198)
扬州市科技项目(YZ2012130)
关键词
糖基化终产物
高级
动脉粥样硬化
糖尿病
晚期糖基化终产物受体
Glycosylation end products,advanced
Atherosclerosis
Diabetes mellitus
Receptor for advanced glycation end products