肺腺癌新增分类及研究新进展

The new addition of classification and study progression of lung adenocarcinoma

腺癌已成为最常见的肺癌类型,肺腺癌无论在临床、影像、分子生物学及病理学方面都存在明显的异质性,过去的肺腺癌分类已无法适应目前的发展,迫切需要一种新的分类标准。2011年国际肺癌研究学会(IASLC)、美国胸科学会(ATS)、欧洲呼吸学会(ERS)联合多学科,结合近年肺腺癌各方面的最新进展,对肺腺癌做出了新的分类。新分类取消了细支气管肺泡癌(BAC)这一分类,新增了4个命名:原位腺癌(AIS)、微浸润腺癌(MIA)、鳞屑样生长为主的浸润性腺癌和浸润性黏液型腺癌。肺腺癌新分类凸现出组织学亚型与分子和临床特征的一些新的相关性,为临床诊疗及科学研究提出了新模式、新方向和新目标。

Adenocarcinoma has become the most common type of lung cancer, lung adenocarcinoma has heterogeneity in the clinic, imaging, molecular biology and pathology, the past classification of lung adenocarcinoma has been unable to adapt to the development now, but needs a new kind of classification standard urgently. In 2011, a new classification of adenocarcinoma of the lung was published by an international multidisciplinary committee sponsored by the International Association for the Study of Lung Cancer （IASLC）, the American Thoracic Society （ATS） and the European Respiratory Society （ERS）, it combined with new developments in recent years. The new classification to cancellthe bronchioloalveolar carcinoma （BAC）, the classification provided four new terms, adenocarcinoma in situ （AIS）, minimally invasive adenocarcinoma （MIA）, lepidic predominant nonmucinous adenocarcinoma and invasive mucinous adenocarcinoma. New classification of adenocarcinoma highlights some new correlations of the histologic subtypes and molecular and clinical features, it puts forward the new mode, new direction and new goals for clinical diagnosis and treatment and scientific research.