抑郁障碍患者脑功能磁共振研究

Research of Brain Functional Magnetic Resonance Imaging on Patients with First-episode Major Depressive Disorder

目的:应用低频振幅(ALFF)分析方法研究首次发病为抑郁障碍的患者脑功能的异常,探讨首发抑郁障碍发病的脑机制。方法:对2011年11月-2013年10月在山西医科大学第一医院收集的13例首发抑郁障碍患者进行脑功能磁共振扫描,另选取14例年龄、性别、受教育年相匹配的正常对照组进行脑功能磁共振扫描,采用汉密尔顿抑郁评分变化测定临床反应。结果:抑郁组与正常对照组比较研究发现右侧中央旁回ALFF值明显大于正常对照组(P<0.05);右侧的岛叶、海马、尾状体的ALFF值明显低于正常对照组(P<0.05)。结论:抑郁障碍患者与正常对照组相比存在静息态脑功能的异常。

Objective：To explore the mechanism of depressive emotion of patients with major depressive disorder （MDD）by the amplitude of low-frequency fluctuations（ALFF）.Method：Resting-state functional magnetic resonance imaging（fMRI）data of 13 MDD patients that met the criteria of DSM-IV（before and after 8-week treatment）and 14 healthy subjects（age,sex,years of education matching）were analyzed with ALFF.Clinical response was measured by change in serial scores on the Hamilton Rating Scale for Depression.Result：Compared with the healthy control,the ALFF of Insula_R（aal）,Hippocampus_R（aal）,Caudate Body were significantly decreased,while Paracentral_Lobule_R（aal）was significantly increased in the untreated first-episode major depressive disorder patients（P〈0.05）.Conclusion：Compared to the control group,the resting-state function of some brain regions are abnormal in patients with depressive disorder.